Linoleic acid has a molecular weight of 280.45 g/mol. Dissolving the full 10 mg tube in 1.43 mL of distilled water yields a 25 millimolar stock solution.
L5900
Linoleic Acid-Water Soluble
powder, BioReagent, suitable for cell culture
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10 MG
MXP 1,244.00
About This Item
UNSPSC Code:
12352211
NACRES:
NA.75
Recommended Products
biological source
plant (Safflower oil)
Quality Level
product line
BioReagent
form
powder
technique(s)
cell culture | mammalian: suitable
solubility
H2O: 50 mg/mL
storage temp.
−20°C
Application
Linoleic acid-water soluble has been used as a component of fatting media for the in vitro steatosis induction of primary human hepatocytes (PHH).[1]
Biochem/physiol Actions
Linoleic acid (LA) is an arachidonic acid precursor,[2] which is present in vegetable oils.[3] It enhances wound healing in diabetic rats.[2] LA triggers tumor and apoptosis in colorectal cancer cells.[3] The levels of LA in adipose tissue and platelets are associated with coronary artery disease.[4] Linoleic acid binds to molecules, such as bovine serum albumin (BSA)[5] or cyclodextrin for use in cell culture.[6]
Other Notes
Contains approx. 30 mg of linoleic acid per gram; balance methyl-β-cyclodextrin.
Package size based on linoleic acid content.
Package size based on linoleic acid content.
related product
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Eye Irrit. 2
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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Articles
Importance and uses of linoleic acid in serum-free eukaryotic, including hybridoma and Chinese Hamster Ovary (CHO) cell, cultures
How the unsaturated fatty acid, oleic acid and other cell culture components affect the performance of serum-free, protein-free cell culture systems used for biomanufacturing heterologous proteins including monoclonal antibodies.
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Hi there, could you confirm the validity of our stock preparation for L5900-10MG? We dissolve the full 10 mg tube in 1.43 mL distilled water, yielding a 25 millimolar stock solution.
1 answer-
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Dear, can you please clarify the composition of this product for me? In my understanding this product contains minimum 2.5% linoleic acid encapsulated in methyl-β-cyclodextrin.
1 answer-
The product contains approximately 30 mg of linoleic acid per gram; balance methyl-?-cyclodextrin.
Package size is based on linoleic acid content.More information can be found in the Data Sheet below:
https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/product/documents/218/859/e8014inf.pdfHelpful?
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How to prepare FAME from it?
1 answer-
This product is designed for use in mammalian cell culture applications as a supplement. If you are seeking a protocol for derivatization of Fatty Acids to FAMEs, please see the following: https://www.sigmaaldrich.com/technical-documents/protocol/food-and-beverage-testing-and-manufacturing/chemical-analysis-for-food-and-beverage/derivatization-of-fatty-acids-to-fames
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