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L2400

Sigma-Aldrich

Lavendustin A

~85% (TLC), crystalline

Synonym(s):

5-[[(2,5-Dihydroxyphenyl)methyl][(2-hydroxyphenyl)methyl]amino]-2-hydroxybenzoic acid

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About This Item

Empirical Formula (Hill Notation):
C21H19NO6
CAS Number:
125697-92-9
Molecular Weight:
381.38
MDL number:
MFCD00153822
UNSPSC Code:
12352200
PubChem Substance ID:
24896314

Assay

~85% (TLC)

form

crystalline

solubility

DMSO: soluble
methanol: soluble

storage temp.

−20°C

SMILES string

OC(=O)c1cc(ccc1O)N(Cc2ccccc2O)Cc3cc(O)ccc3O

InChI

1S/C21H19NO6/c23-16-6-8-19(25)14(9-16)12-22(11-13-3-1-2-4-18(13)24)15-5-7-20(26)17(10-15)21(27)28/h1-10,23-26H,11-12H2,(H,27,28)

InChI key

ULTTYPMRMMDONC-UHFFFAOYSA-N

Gene Information

human ... EGFR(1956) , ERBB2(2064) , LCK(3932)

Biochem/physiol Actions

Cell-permeable tyrosine kinase inhibitor with little effect on protein kinase A or C. Inhibits NMDA-stimulated cGMP production. Inhibits VEGF-induced angiogenesis.

Physical form

Photosensitive

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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C C Huang et al.
The Journal of physiology, 520 Pt 3, 783-796 (1999-11-02)
1. Protein tyrosine phosphorylation is thought to play an important role in the regulation of neuronal function. Previous work has shown that protein tyrosine kinase (PTK) inhibitors can inhibit the induction of long-term potentiation (LTP), a candidate synaptic mechanism involved
D Spicarova et al.
Neuroscience, 166(1), 305-311 (2009-12-17)
Glutamate AMPA receptors are critical for sensory transmission at the spinal cord dorsal horn (DH). Plasma membrane AMPA receptor endocytosis that can be induced by insulin may underlie long term modulation of synaptic transmission. Insulin receptors (IRs) are known to
Shi-Sheng Zhou et al.
Experimental physiology, 92(3), 549-559 (2007-02-17)
The effects of monocarboxylic acid-derived Cl(-) channel blockers on cardiac depolarization-activated K(+) currents were investigated. Membrane currents in rat ventricular myocytes were recorded using the whole-cell configuration of the patch-clamp technique. 5-Nitro-2-(3-phenylpropylamino)-benzoic acid (NPPB) and niflumic acid (NFA) induced an
Marek Opałka et al.
Reproductive biology, 6 Suppl 2, 47-54 (2007-01-16)
The mechanism of phytoestrogen action in gonadal cells of ganders has not been elucidated. The aim of the study was to investigate in Biłgoraj ganders the possibility of phytoestrogen action via estrogen or androgen receptors or via protein tyrosine kinase
Kristin Löber et al.
Journal of cellular biochemistry, 103(4), 1076-1088 (2007-07-31)
The human mast cell line (HMC-1(560)) was used to study the effects of tyrosine kinase (TyrK) inhibition on histamine release in consequence of intracellular Ca2+ or pH changes. This is important since the TyrK inhibitor STI571 (Glivec) inhibits proliferation and
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