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L0664

Sigma-Aldrich

Loxoprofen

solid

Synonym(s):

α-Methyl-4-[(2-oxocyclopentyl)methyl]benzeneacetic acid, Koloxo

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About This Item

Empirical Formula (Hill Notation):
C15H18O3
CAS Number:
68767-14-6
Molecular Weight:
246.30
MDL number:
MFCD00864331
UNSPSC Code:
12352200
PubChem Substance ID:
24278509
NACRES:
NA.77

form

solid

originator

Daiichi-Sankyo

SMILES string

CC(C(O)=O)c1ccc(CC2CCCC2=O)cc1

InChI

1S/C15H18O3/c1-10(15(17)18)12-7-5-11(6-8-12)9-13-3-2-4-14(13)16/h5-8,10,13H,2-4,9H2,1H3,(H,17,18)

InChI key

YMBXTVYHTMGZDW-UHFFFAOYSA-N

Gene Information

human ... PTGS1(5742) , PTGS2(5743)

Application

Anti-inflammatory; analgesic

Features and Benefits

This compound was developed by Daiichi-Sankyo. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Misato Hashizume et al.
Modern rheumatology, 20(5), 432-438 (2010-04-22)
We examined the therapeutic effect of high molecular weight hyaluronic acid (HA) on the progression of joint pain and cartilage degeneration in a rabbit osteoarthritis (OA) model. The OA model was induced by partial meniscectomy. In the time course study
Yasushi Kuribayashi et al.
The journal of obstetrics and gynaecology research, 43(9), 1465-1471 (2017-07-15)
We aimed to determine the frequency of endometrial cancer in infertile women undergoing hysteroscopic endometrial polypectomy for endometrial polyps. A total of 1035 infertile patients who underwent office-based hysteroscopic polypectomy at Sugiyama Clinic Marunouchi between July 2011 and October 2015
M Sugimoto et al.
Biochemical pharmacology, 42(12), 2363-2368 (1991-11-27)
The effect of loxoprofen-Na, a novel non-steroidal anti-inflammatory drug with a prodrug property, on prostaglandin (PG) levels in the inflammatory tissue was investigated with a carrageenin-induced pleurisy model in rats. The intrapleural injection of carrageenin caused a marked increase in
Teruya Komatsu et al.
International journal of surgery (London, England), 12(9), 936-939 (2014-08-06)
Appropriate postoperative analgesia is crucial in fast-track surgery, which is a multimodal therapeutic strategy that aims toward enhanced postoperative recovery and shortened hospital stay. Paravertebral block (PVB) has been reported to be as effective as thoracic epidural blockade (TEB), but
C Sakamoto et al.
Alimentary pharmacology & therapeutics, 37(3), 346-354 (2012-12-12)
Although nonsteroidal anti-inflammatory drugs (NSAIDs) are widely prescribed globally, their chronic use increases the risk of upper gastrointestinal (GI) damage. Cyclooxygenase-2-selective NSAIDs are considered to reduce this risk. Current guidelines in Japan recommend loxoprofen sodium (loxoprofen), a pro-drug in the
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