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H5520

Sigma-Aldrich

17α-Hydroxyprogesterone hexanoate

≥98%

Synonym(s):

17α-Hydroxyprogesterone caproate

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About This Item

Empirical Formula (Hill Notation):
C27H40O4
CAS Number:
630-56-8
Molecular Weight:
428.60
EC Number:
211-138-8
MDL number:
MFCD00072134
UNSPSC Code:
12352200
PubChem Substance ID:
24895697

Assay

≥98%

SMILES string

[H][C@@]12CCC3=CC(=O)CC[C@]3(C)[C@@]1([H])CC[C@@]4(C)[C@@]2([H])CC[C@]4(OC(=O)CCCCC)C(C)=O

InChI

1S/C27H40O4/c1-5-6-7-8-24(30)31-27(18(2)28)16-13-23-21-10-9-19-17-20(29)11-14-25(19,3)22(21)12-15-26(23,27)4/h17,21-23H,5-16H2,1-4H3/t21-,22+,23+,25+,26+,27+/m1/s1

InChI key

DOMWKUIIPQCAJU-LJHIYBGHSA-N

Gene Information

human ... PGR(5241)

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Biochem/physiol Actions

Shows significant reduction of pre-term delivery by mothers with a history of premature delivery, with no detectable harm to the infant.

Pictograms

Health hazard
GHS08

Signal Word

Danger

Hazard Statements

H360

Precautionary Statements

P201 - P308 + P313

Hazard Classifications

Repr. 1B

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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Baha M Sibai et al.
American journal of perinatology, 29(8), 635-642 (2012-05-12)
To examine pregnancy outcomes of women receiving weekly compounded 17 α-hydroxyprogesterone caproate (17P) injections through a home nursing program compared with those reported in a multicenter trial by the Eunice Kennedy Shriver National Institute of Child Health and Human Development
William A Grobman et al.
American journal of obstetrics and gynecology, 207(5), 390-390 (2012-09-27)
We sought to evaluate whether 17 alpha-hydroxyprogesterone caproate (17-OHP) reduces preterm birth (PTB) in nulliparous women with a midtrimester cervical length (CL) <30 mm. In this multicenter randomized controlled trial, nulliparous women with a singleton gestation between 16 and 22
A C Lim et al.
Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology, 40(4), 426-430 (2012-09-26)
Previous studies on singleton pregnancies have indicated that progestogens may reduce the rate of cervical shortening during pregnancy. The aim of this study was to investigate whether treatment with 17-alpha hydroxyprogesterone caproate (17-OHPC) has an effect on cervical shortening in
Courtney D Cuppett et al.
American journal of obstetrics and gynecology, 208(1), 86-86 (2012-10-16)
Plasma concentrations of 17-alpha-hydroxyprogesterone caproate (17-OHPC) vary substantially in pregnant patients who receive an identical dose. Endogenous steroid hormones may alter 17-OHPC metabolism, which contributes to this large variability. Pooled human liver microsomes were incubated with 17-OHPC alone or in
Steve N Caritis et al.
American journal of obstetrics and gynecology, 208(6), 470-470 (2013-03-05)
17-alpha hydroxyprogesterone caproate (17-OHPC) is available both as an Food and Drug Administration (FDA)-approved medication and as a product prepared for individual patients by compounding pharmacies. Compounding pharmacies may omit the preservative that is used in the FDA-approved formulation or
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