No specific suitability tests for cell culture applications have been performed by Sigma. The product is not sterile and has not been tested for endotoxins.
E8750
α-Estradiol
powder, ≥98% (TLC)
Synonym(s):
1,3,5(10)-Estratriene-3,17α-diol, 3,17α-Dihydroxy-1,3,5(10)-estratriene, Epiestradiol
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100 MG
MXP 3,294.00
500 MG
MXP 9,495.00
1 G
MXP 15,630.00
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100 MG
MXP 3,294.00
500 MG
MXP 9,495.00
1 G
MXP 15,630.00
About This Item
Empirical Formula (Hill Notation):
C18H24O2
CAS Number:
Molecular Weight:
272.38
EC Number:
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
Recommended Products
biological source
synthetic (organic)
Quality Level
Assay
≥98% (TLC)
form
powder
color
white to slight yellow
solubility
ethanol: 50 mg/mL, clear, colorless
shipped in
ambient
storage temp.
room temp
SMILES string
[H][C@]12CC[C@]3(C)[C@H](O)CC[C@@]3([H])[C@]1([H])CCc4cc(O)ccc24
InChI
1S/C18H24O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-17,19-20H,2,4,6-9H2,1H3/t14-,15-,16+,17-,18+/m1/s1
InChI key
VOXZDWNPVJITMN-SFFUCWETSA-N
Gene Information
human ... ESR1(2099) , ESR2(2100)
rat ... Ar(24208)
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Biochem/physiol Actions
Estradiol (known as alpha Estradiol or 17 alpha Estradiol) is a biologically active estrogen in human breast cancer cells in tissue culture.17-estradiol and its selective receptor, ER-X, are not part of a classical hormone/receptor endocrine system but of a system with important autocrine/paracrine functions in the developing and adult brain. 17-Estradiol may have enormous implications for hormone replacement strategies at the menopause and in the treatment of such neurodegenerative disorders as Alzheimer′s disease and ischemic stroke.
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Aquatic Chronic 1 - Carc. 2 - Lact. - Muta. 2 - Repr. 1A
Storage Class Code
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 3
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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Is Product E8750, α-Estradiol, tested in cell culture?
1 answer-
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What is the Department of Transportation shipping information for this product?
1 answer-
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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What is the difference between α-Estradiol (Product No. E8750) and β-Estradiol?
1 answer-
α-Estradiol has been reported as being less feminizing than β-Estradiol while still having significant biological properties. See Moos, W.H., et al, "17α-Estradiol:a less-feminizing estrogen", Drug Development Research, 69(4), 177-184 (2008).
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How can I dissolve α-Estradiol, Product No. E8750?
1 answer-
This chemical is soluble in ethanol at 50 mg/mL with heating, and in DMSO at 27 mg/mL. Use of freshly prepared solutions is recommended.
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How does the storage temperature relate to shipping conditions?
1 answer-
The storage conditions that a Sigma-Aldrich catalog and label recommend for products are deliberately conservative. For many products, long-term storage at low temperatures will increase the time during which they are expected to remain in specification and therefore are labeled accordingly. Where short-term storage, shipping time frame, or exposure to conditions other than those recommended for long-term storage will not affect product quality, Sigma-Aldrich will ship at ambient temperature. The products sensitive to short-term exposure to conditions other than their recommended long-term storage are shipped on wet or dry ice. Ambient temperature shipping helps to control shipping costs for our customers. At any time, our customers can request wet- or dry-ice shipment, but the special handling is at customer expense if our product history indicates that the product is stable for regular shipment.
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