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D4196

Dehydroleucodine

≥98% (HPLC)

Synonym(s):

11,13-Dehydroleucodin, Dehydroleucodin, Leucodin, Lidbeckialactone, Mesatlantin E, NSC 180034, [3aS-(3aalpha,9aalpha,9bbeta)]-3,3a,4,5,9a,9b-hexahydro-6,9-dimethyl-3-methylene-azuleno[4,5-b]furan-2,7-dione, dehydro-

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5 mg
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MXP 2,265.00
25 mg
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MXP 7,181.00

About This Item

Empirical Formula (Hill Notation):
C15H16O3
CAS Number:
36150-07-9
Molecular Weight:
244.29
NACRES:
NA.77
PubChem Substance ID:
329798795
UNSPSC Code:
12352200
MDL number:
MFCD06794926
Assay:
≥98% (HPLC)
Form:
powder
Quality level:
100
Storage condition:
desiccated, protect from light

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Quality Level

100

assay

≥98% (HPLC)

form

powder

storage condition

desiccated, protect from light

color

white to off-white

solubility

DMSO: ≥30 mg/mL

storage temp.

room temp

SMILES string

CC1=C2[C@@H]([C@H]3OC(=O)C(=C)[C@@H]3CC1)C(C)=CC2=O

InChI

1S/C15H16O3/c1-7-4-5-10-9(3)15(17)18-14(10)13-8(2)6-11(16)12(7)13/h6,10,13-14H,3-5H2,1-2H3/t10-,13-,14-/m0/s1

InChI key

SKNVIAFTENCNGB-BPNCWPANSA-N

Biochem/physiol Actions

Dehydroleucodine is a sesquiterpene lactone isolated from Artemisia douglasiana Besser; mast cell stabilizers.
Dehydroleucodine is a sesquiterpene lactone isolated from Artemisia douglasiana Besser; mast cell stabilizers. An extract from the plant is widely used in Cuyo region (Argentina) as folk medicine for the treatment of gastric ailments. The compound prevents gastric and duodenal damages in response to necrosis-inducing agents. Stabilization of mast cells may be a key mechanism to protect the gastrointestinal tract from injury and ulceration. Recently, it was established that dehydroleucodine and xanthatin inhibit mast cell degranulation induced by compound 48/80.

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Dehydroleucodine ≥98% (HPLC)

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Sigma-Aldrich

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Drospirenone ≥98% (HPLC)

Sigma-Aldrich

SML0147

Drospirenone

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Sigma-Aldrich

SML1570

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form

powder

form

powder

form

powder

form

powder

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

Quality Level

100

Quality Level

200

Quality Level

100

Quality Level

100

storage temp.

room temp

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

−20°C

solubility

DMSO: ≥30 mg/mL

solubility

methanol: 25 mg/mL

solubility

DMSO: ≥15

solubility

-

storage condition

desiccated, protect from light

storage condition

-

storage condition

desiccated

storage condition

protect from light

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000402290
0000402291
0000402290
0000402291
0000174874

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Graciela Haydée Wendel et al.
European biophysics journal : EBJ, 40(8), 981-986 (2011-06-15)
The activity of dehydroleucodine, a sesquiterpene lactone obtained from Artemisia douglasiana, was studied in mice small intestinal transit. Its mechanism was evaluated in the presence of several adrenergic and cholinergic antagonist drugs and one opioid antagonist. Docking of dehydroleucodine into
M Cruzado et al.
Cellular and molecular biology (Noisy-le-Grand, France), 51(6), 525-530 (2005-11-29)
Vascular smooth muscle cell (VSMC) proliferation plays an important role in the development of atherosclerosis and in the vascular changes seen in hypertension. Dehydroleucodine (DhL) is a sesquiterpene lactone that inhibits cell proliferation in plant cells. In this paper, we
M E López et al.
Protoplasma, 219(1-2), 82-88 (2002-04-03)
Dehydroleucodine is a sesquiterpene lactone recently isolated from aerial parts of a medicinal herb, Artemisia douglasiana Besser. We have previously shown that 25 and 100 microM dehydroleucodine slowed down onion root growth by 30 and 70%, respectively, affecting neither cell
View All Related Papers

Global Trade Item Number

SKUGTIN
D4196-5MG04061832631943
D4196-25MG04061832631936

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