CD27, a member of tumour necrosis factor receptor superfamily is mainly responsible for regulation of cell proliferation and cell death. CD27 and its ligand CD70 expresses mainly on lymphocytes. Anti-CD27 antibody can be used in immunoblotting and flow cytometry. It can also be used in immunopresipitating CD27. Anti-CD27 antibody reacts specifically with human CD27 and not with recombinant human CD30, recombinant human NGF R, recombinant human soluble TNF RI, or recombinant human soluble TNF RII.
Immunogen
recombinant human CD27 extracellular domain expressed in Sf2I insect cells.
Application
Anti-CD27 antibody can be used in neutralization, immunoblotting and indirect flow cytometry assays.
Physical form
Lyophilized from 0.2 μm filtered solution of phosphate buffered saline with 5% trehalose.
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Proceedings of the National Academy of Sciences of the United States of America, 94(12), 6346-6351 (1997-06-10)
Members of the tumor necrosis factor receptor (TNFR) superfamily are important for cell growth and survival. In addition to providing costimulatory signals for cell proliferation, ligation of both TNFR1 and Fas can result in programmed cell death or apoptosis. The
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