as a fatty acid synthase (FASN) inhibitor to test its ability in the direct inhibition of FASN to attenuate mammosphere formation as compared to metformin[1]
as a pharmacological inhibitor to inhibit fatty acid synthesis in glioma stem cells (GSCs)[2]
as FASinhibitorin the pre-treatment of Chang cells to inhibit lipogenesis and reverse the senescence induced by hydrogen peroxide[3]
Biochem/physiol Actions
C75 helps to increase the cancer‐killing capability of ionizing radiation.[4]
C75 is a novel, potent synthetic inhibitor of fatty acid synthase (FAS), which is used as a tool for studying fatty acid synthesis in metabolic disorders and cancer.
Leprosy is a chronic infectious disease that is caused by the obligate intracellular pathogen Mycobacterium leprae (M.leprae), which is the leading cause of all non-traumatic peripheral neuropathies worldwide. Although both myelinating and non-myelinating Schwann cells are infected by M.leprae in
Differential in radiosensitizing potency of enantiomers of the fatty acid synthase inhibitor C75
Posttranscriptional modifications are critical for structure and function of tRNAs. Wybutosine (yW) and its derivatives are hyper-modified guanosines found at the position 37 of eukaryotic and archaeal tRNA(Phe). TYW2 is an enzyme that catalyzes α-amino-α-carboxypropyl transfer activity at the third
Analytical and bioanalytical chemistry, 408(30), 8583-8591 (2016-04-02)
There are various ways that priming can occur in nucleic acid amplification reactions. While most reactions rely on a primer to initiate amplification, a mechanism for DNA amplification has been developed in which hairpin sequences at the 3' terminus of
Post-transcriptional modifications of ribosomal RNAs (rRNAs) are involved in ribosome biogenesis and fine-tuning of translation. 5-Hydroxycytidine (ho5C), a modification of unknown biogenesis and function, is present at position 2501 of Escherichia coli 23S rRNA. We conducted a genome-wide screen in
Discover Bioactive Small Molecules for Lipid Signaling Research
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