Synthetic peptide directed towards the C terminal region of human PIAS2
Biochem/physiol Actions
Protein inhibitor of activated STAT (PIAS) family of proteins mediates the sumoylation of proteins by acting as SUMO E3 ligases. Some important proteins that are sumoylated by PIAS are p53, c-Jun and the androgen receptor.
Sequence
Synthetic peptide located within the following region: LTSPLTASSTSVTTTSSHESSTHVSSSSSRSETGVITSSGSNIPDIISLD
Physical form
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
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Developmental dynamics : an official publication of the American Association of Anatomists, 240(9), 2120-2126 (2011-07-23)
Originally identified as cytokine inhibitors, protein inhibitors of activated STAT (PIAS) are shown to regulate activities of a plethora of proteins and influence diverse processes such as immune response, cancer formation, and cell cycle progression. However, the roles of PIAS
GTF2IRD1 is one of the genes implicated in Williams-Beuren syndrome, a disease caused by haploinsufficiency of certain dosage-sensitive genes within a hemizygous microdeletion of chromosome 7. GTF2IRD1 is a prime candidate for some of the major features of the disease
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