MyCN is a basic helix-loop-helix protein that has been implicated neuroblastomas. Studies have linked childhood neuroblastomas with MyCN amplifications to caspase 8 supression. Rabbit Anti-MyCN antibody recognizes rat, canine, mouse, and human MyCN.
Immunogen
Synthetic peptide directed towards the C terminal region of human MYCN
Application
Rabbit Anti-MyCN antibody can be used for western blot applications at a concentration of 2.5μg/ml.
Biochem/physiol Actions
MYCN is a member of the MYC family and encodes a protein with a basic helix-loop-helix (bHLH) domain. It is located in the nucleus and must dimerize with another bHLH protein in order to bind DNA. Amplification of this gene is associated with a variety of tumors, most notably neuroblastomas
Sequence
Synthetic peptide located within the following region: EDAPPQKKIKSEASPRPLKSVIPPKAKSLSPRNSDSEDSERRRNHNILER
Physical form
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Caspase 8 is a cysteine protease regulated in both a death-receptor-dependent and -independent manner during apoptosis. Here, we report that the gene for caspase 8 is frequently inactivated in neuroblastoma, a childhood tumor of the peripheral nervous system. The gene
Questions
Reviews
★★★★★ No rating value
Active Filters
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
