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A7384

Sigma-Aldrich

Agaric acid

Synonym(s):

2-Hydroxy-1,2,3-nona­decane­tricarboxylic acid, Agaricic acid, Agaricin

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About This Item

Empirical Formula (Hill Notation):
C22H40O7
CAS Number:
666-99-9
Molecular Weight:
416.55
EC Number:
211-566-5
MDL number:
MFCD00002665
UNSPSC Code:
12352201
PubChem Substance ID:
24891123
NACRES:
NA.25

form

powder

SMILES string

CCCCCCCCCCCCCCCCC(C(O)=O)C(O)(CC(O)=O)C(O)=O

InChI

1S/C22H40O7/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-18(20(25)26)22(29,21(27)28)17-19(23)24/h18,29H,2-17H2,1H3,(H,23,24)(H,25,26)(H,27,28)

InChI key

HZLCGUXUOFWCCN-UHFFFAOYSA-N

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Application

Agaric acid (Agaricic acid), an inducer of mitochondrial permeability transition (MPT), is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase.

Other Notes

To gain a comprehensive understanding of our extensive range of Monosaccharides for your research, we encourage you to visit our Carbohydrates Category page.

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

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L Wojtczak et al.
Journal of bioenergetics and biomembranes, 31(5), 447-455 (2000-02-01)
Nonesterified long-chain fatty acids have long been known as uncouplers of oxidative phosphorylation. They are efficient protonophores in the inner mitochondrial membrane but not so in artificial phospholipid membranes. In the un-ionized form, they undergo a rapid spontaneous transbilayer movement
Noemí García et al.
Cell biochemistry and biophysics, 51(2-3), 81-87 (2008-07-24)
In this work, we studied the effect of N-ethylmaleimide on permeability transition. The findings indicate that the amine inhibited the effects of carboxyatractyloside and agaric acid. It is known that these reagents interact with the adenine nucleotide carrier through the
J Kanaani et al.
The Journal of biological chemistry, 264(6), 3194-3199 (1989-02-25)
The metabolic inter-relationships between malarial parasites and their host erythrocytes are poorly understood. They have been investigated hitherto mostly by observing parasite behavior in erythrocyte variants, in metabolically altered erythrocytes, or in cell-free in vitro systems. We have studied the
Agaric acid.
R A Freedland et al.
Methods in enzymology, 72, 497-506 (1981-01-01)
Hai-Ling Zhang et al.
Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae, 28(4), 486-491 (2006-09-26)
To evaluate the effects of arginine modified chitosan or hexadecylated modified chitosan as gene carriers on the cellular uptake by vascular smooth muscle cells and its in vitro cytotoxicity. METHODS Plasmid DNA was labeled with alpha-32P-dATP and complexed with the
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