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About This Item
Empirical Formula (Hill Notation):
C9H11N5O4
CAS Number:
Molecular Weight:
253.21
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
Assay
≥98% (TLC)
storage temp.
−20°C
SMILES string
OC[C@H]1O[C@H](C[C@H]1N=[N+]=[N-])N2C=CC(=O)NC2=O
Application
3′-Azido-2′,3′-dideoxyuridine has shown potent anti-HIV activity in vitro.
Biochem/physiol Actions
Inhibitor of HIV replication.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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Z Zhu et al.
Molecular pharmacology, 38(6), 929-938 (1990-12-01)
3'-Azido-2',3'-dideoxyuridine (AzdU, CS-87) is a potent inhibitor of human immunodeficiency virus replication in human peripheral blood mononuclear cells (PBMC) with limited toxicity for human bone marrow cells (BMC). In the present study, metabolism of AzdU was investigated in human PBMC
Linghui Kong et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 795(2), 371-376 (2003-10-03)
3'-Azido-2',3'-dideoxyuridine (AZDU) is a nucleoside analog structurally similar to zidovudine (AZT) with proven activity against human immunodeficiency virus (HIV). The purpose of this study was to develop and validate a high-performance liquid chromatographic (HPLC) method to quantitatively determine AZDU and
K K Manouilov et al.
Drug metabolism and disposition: the biological fate of chemicals, 23(6), 655-658 (1995-06-01)
Recently, it was shown that human immunodeficiency virus (HIV)-infected cells preferentially locate in lymphoid tissue early in the course of infection. Therefore, it is important to characterize the disposition of the anti-HIV agents, 3'-azido-3'-deoxythymidine (AZT) and 3'-azido-2', 3'-dideoxyuridine (AZdU), in
A Resetar et al.
Biochemical pharmacology, 42(3), 559-568 (1991-07-15)
The enzymatic glucuronidation of 3'-azido-3'-deoxythymidine (AZT) catalyzed by human liver microsomal UDP-glucuronosyltransferase (EC 2.4.1.17, UDPGT) was inhibited by a number of nucleoside analogs. The inhibitory potency of these nucleoside analogs correlated with their hydrophobicity (r2 = 0.90, N = 13).
K J Doshi et al.
Drug metabolism and disposition: the biological fate of chemicals, 17(6), 590-594 (1989-11-01)
The pharmacokinetics of 3'-azido-3'-deoxythymidine (AZT) and 3'-azido-2',3'-dideoxyuridine (AZddU, CS-87), active anti-HIV compounds, were characterized in uninfected mice. Sensitive and specific HPLC techniques were used to quantitate AZT and AZddU concentrations in serum and brain homogenates following iv doses of 50
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