Skip to Content
Merck
All Photos(1)

Key Documents

A4056

Sigma-Aldrich

Amrinone

Synonym(s):

5-Amino-(3,4′-bipyridin)-6(1H)-one, Inamrinone

Sign Into View Organizational & Contract Pricing


About This Item

Empirical Formula (Hill Notation):
C10H9N3O
CAS Number:
Molecular Weight:
187.20
EC Number:
MDL number:
UNSPSC Code:
12352202
PubChem Substance ID:

Assay

≥98% (TLC)

Quality Level

form

powder

solubility

1 M NaOH: 100 mg/mL

storage temp.

2-8°C

SMILES string

NC1=CC(=CNC1=O)c2ccncc2

InChI

1S/C10H9N3O/c11-9-5-8(6-13-10(9)14)7-1-3-12-4-2-7/h1-6H,11H2,(H,13,14)

InChI key

RNLQIBCLLYYYFJ-UHFFFAOYSA-N

Gene Information

human ... PDE3A(5139)
rat ... Pde3a(50678)

Looking for similar products? Visit Product Comparison Guide

Biochem/physiol Actions

Simple, non-glycoside cardiotonic agent, possibly via its phosphodiesterase III (PDE-III) inhibitory action.[1]
Simple, non-glycoside cardiotonic agent, possibly via its phosphodiesterase III (PDE-III) inhibitory action.[1] Independent of its cardiac effects, amrinone provides protection against ischemia-reperfusion injury in kidney,[2] liver,[3] and heart.[4]

Pictograms

Skull and crossbones

Signal Word

Danger

Hazard Statements

Precautionary Statements

Hazard Classifications

Acute Tox. 3 Oral

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Kazuo Komamura et al.
Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research, 11 Suppl 1, S39-S42 (2008-04-17)
Phosphodiesterase (PDE) III inhibitor therapy is effective for treatment of acute decompensated heart failure (ADHF). Nevertheless, this drug is expensive than conventional inotropic agent dobutamine. We compared total medication costs of the patients treated with PDE III inhibitor amrinone therapy
M P Rechtman et al.
European journal of pharmacology, 402(3), 255-262 (2000-08-26)
We investigated the effects of amrinone on ischaemia-induced changes in myocardial function in isolated rat hearts. Isolated hearts from male Sprague-Dawley rats (150-275 g) were perfused with physiological salt solution at a constant flow rate. The effects of amrinone (30
Kiyokazu Yunomae et al.
Journal of applied toxicology : JAT, 27(1), 78-85 (2006-12-06)
It is presumed that phosphodiesterase (PDE) inhibitors have two mechanisms for inhibition of hERG currents in the acute applications to cells: direct channel block, and downregulation of human ether-a-go-go related gene (hERG) activities by PKA-dependent pathway mediated phosphorylation through their
Greene Shepherd
American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 63(19), 1828-1835 (2006-09-23)
The toxic effects and treatment of beta-adrenergic blocker and calcium-channel blocker (CCB) overdose are reviewed. Overdoses with cardiovascular drugs are associated with significant morbidity and mortality. Beta-blockers and CCBs represent the most important classes of cardiovascular drugs. In overdose, beta-blockers
Alousi, A.A., et al.
Federation Proceedings, 37, 3692-3692 (1978)

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service