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A2407

Sigma-Aldrich

Adrenocorticotropic Hormone Fragment 1-17 human, rat

≥97% (HPLC)

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About This Item

Empirical Formula (Hill Notation):
C95H145N29O23S
CAS Number:
7266-47-9
Molecular Weight:
2093.41
MDL number:
MFCD00133033
UNSPSC Code:
51111800
PubChem Substance ID:
329770781
NACRES:
NA.32

sterility

non-sterile

Quality Level

200

Assay

≥97% (HPLC)

form

powder

UniProt accession no.

P01189

storage temp.

−20°C

SMILES string

CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CO)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc4c[nH]c5ccccc45)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N6CCC[C@H]6C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O

InChI

1S/C95H145N29O23S/c1-53(2)78(91(144)109-49-75(128)111-62(22-9-12-35-96)81(134)113-63(23-10-13-36-97)82(135)117-68(93(146)147)26-16-39-106-95(102)103)123-90(143)74-27-17-40-124(74)92(145)67(24-11-14-37-98)112-76(129)48-108-80(133)71(44-56-46-107-61-21-8-7-20-59(56)61)120-83(136)64(25-15-38-105-94(100)101)114-86(139)70(42-54-18-5-4-6-19-54)119-88(141)72(45-57-47-104-52-110-57)121-84(137)65(32-33-77(130)131)115-85(138)66(34-41-148-3)116-89(142)73(51-126)122-87(140)69(118-79(132)60(99)50-125)43-55-28-30-58(127)31-29-55/h4-8,18-21,28-31,46-47,52-53,60,62-74,78,107,125-127H,9-17,22-27,32-45,48-51,96-99H2,1-3H3,(H,104,110)(H,108,133)(H,109,144)(H,111,128)(H,112,129)(H,113,134)(H,114,139)(H,115,138)(H,116,142)(H,117,135)(H,118,132)(H,119,141)(H,120,136)(H,121,137)(H,122,140)(H,123,143)(H,130,131)(H,146,147)(H4,100,101,105)(H4,102,103,106)/t60-,62-,63-,64-,65-,66-,67-,68-,69-,70-,71-,72-,73-,74-,78-/m0/s1

InChI key

MXNMAFWEFLFAJN-QBQLSIIBSA-N

Gene Information

human ... POMC(5443)

Amino Acid Sequence

Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-Gly-Lys-Lys-Arg

Biochem/physiol Actions

ACTH fragment with moderate adrenocorticotropic and melanocyte-stimulating activities.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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R Valentino et al.
Nutrition, metabolism, and cardiovascular diseases : NMCD, 9(4), 192-195 (1999-12-30)
The aim of this study was to determine the validity of our previous hypothesis of adrenal 11 beta-hydroxylase (11-OH) dysregulation in "essential" low-renin hypertension. A comparison was made between 30 hypertensive patients and 30 age-matched controls (NC) in basal conditions
Effect of a synthetic short-chain ACTH 1-17 (HOE 433) on isoproterenol-induced myocardial infarction in rats.
S Asha Devi
Indian journal of experimental biology, 26(9), 685-687 (1988-09-01)
F Iannotta et al.
Chronobiologia, 14(1), 39-46 (1987-01-01)
The effects of 100 micrograms, i.m. of the analog ACTH 1-17 administered at 0800 and 1800 on the secretion of cortisol, aldosterone and testosterone have been studied in normal subjects: 8 male and 8 female. The group as a whole
G Nappi et al.
Acta neurologica Scandinavica, 78(2), 146-151 (1988-08-01)
Eleven patients with presenile Alzheimer type dementia (ATD) were treated with N-terminal ACTH fragments for 14 days. No change in cognitive functions was observed during the treatment. A significant increase in CSF beta-endorphin (beta-EP) levels was found, while ACTH and
G P Ceda et al.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 19(8), 361-363 (1987-08-01)
Recently we demonstrated that ACTH 1-17 infusion in normal subjects is able to stimulate growth hormone (GH) secretion. In order to study the mechanism by which ACTH 1-17 induces this hormonal secretory pattern, we examined the effects of ACTH 1-17
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