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94378

Sigma-Aldrich

Methyl cellulose

viscosity 3000-5500 mPa.s, 2 % in H2O(20 °C)

Synonym(s):

Methyl cellulose

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Estimated to ship onApril 11, 2025

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About This Item

CAS Number:
9004-67-5
MDL number:
MFCD00081763
UNSPSC Code:
12352204
NACRES:
NA.25

MXP 4,779.00

Estimated to ship onApril 11, 2025

Request a Bulk Order

form

powder

Quality Level

100

viscosity

3000-5500 mPa.s, 2 % in H2O(20 °C)

SMILES string

[*]OC[C@H]1O[C@@H](O[C@@H]2[C@@H](CO[*])O[C@@H](O[*])[C@H](O[*])[C@H]2O[*])[C@H](O[*])[C@@H](O[*])[C@@H]1O[*]

InChI key

YLGXILFCIXHCMC-JHGZEJCSSA-N

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General description

Methyl cellulose is a gum polysaccharide containing glucose with methyl substitution.[1]

Application

Methyl cellulose has been used:


  • in polymer solution to enhance viscosity in the formulation for dip coating[2]
  • in growth medium to facilitate stable morphology[3]
  • as a supplement in HMI-9 medium to increase viscosity[4]

Biochem/physiol Actions

Methyl cellulose is known to have a molecular size that might pass through placenta.[5] It is useful in visualizing small bowel loops through its overlaps.[6]

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
BCCL0096
BCCJ6349
BCCH4207
BCCG2316
BCCF7450

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Impact insertion of transfer-molded microneedle for localized and minimally invasive ocular drug delivery
Song HB, et al.
Journal of Controlled Release : Official Journal of the Controlled Release Society, 209, 272-279 (2015)
A quorum sensing-independent path to stumpy development in Trypanosoma brucei
Zimmermann H, et al.
PLoS Pathogens, 13(4), e1006324-e1006324 (2017)
Methylcellulose and Bacterial Motility.
A Pijper
Journal of bacteriology, 53(3), 257-269 (1947-03-01)
Sarah Schuster et al.
eLife, 10 (2021-08-07)
African trypanosomes cause sleeping sickness in humans and nagana in cattle. These unicellular parasites are transmitted by the bloodsucking tsetse fly. In the mammalian host's circulation, proliferating slender stage cells differentiate into cell cycle-arrested stumpy stage cells when they reach
Bronchopulmonary infection due to Branhamella catarrhalis.
DT McLeod, F Ahmad, et al.
British Medical Journal, 287, 1446-1447 (1983)
View All Related Papers

Questions

  1. What is the difference chemically speaking and in characteristics of these two compounds? Regarding particle size and its properties, Cat # 94378 Methocel® A4M vs M0512 Methylcellulose both have the same CAS Number: 9004-67-5

    1 answer

    1. Product 94378 (Methocel® A4M) in a 2% solution in water at 20°C results in a solution with a viscosity between 3000 - 5500 mPa.s. While not directly analyzed for particle size, it is suggested that it is primarily -40 mesh or smaller than 420 micron. Molecular weight information is not determined.

      Product M0512 in a 2% solution in water at 20°C results in a solution with a viscosity between 3500 - 5600 cps. The particle size for product M0512 is not analyzed. The M0512 lists an approximate molecular weight of 88,000 with methoxy substitution between 27.5 - 31.5% (weight).

      https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/product/documents/251/785/m0512pis.pdf

      Both products are methyl cellulose polymers. The major application that Dupont lists for their Methocel A4M is in ceramic extrusion. It seems to have a similar reported methoxy content as shown in Dow's brochure below.

      https://cms.chempoint.com/ChemPoint/media/Methocel-brochure/Methocel-Brochure-2019-1.pdf

      Thus, the primary difference between these two products would be the manufacturer's origin.

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