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46945

Sigma-Aldrich

Fluorescein isothiocyanate–dextran

average mol wt 70,000, (FITC:Glucose = 1:250)

Synonym(s):

FITC-Dextran 70, FITC–Dextran

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100 MG
MXP 3,648.00
500 MG
MXP 12,835.00

MXP 3,648.00

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100 MG
MXP 3,648.00
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MXP 12,835.00

About This Item

CAS Number:
60842-46-8
MDL number:
MFCD00131092
UNSPSC Code:
12352201
NACRES:
NA.32

MXP 3,648.00

In StockDetails

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biological source

synthetic

Quality Level

100

conjugate

FITC conjugate

form

powder

mol wt

average mol wt 70,000

composition

(FITC:Glucose = 1:250)

extent of labeling

~0.004 mol/mol FITC glucose

solubility

H2O: 50 mg/mL, hazy, orange to very deep orange

fluorescence

λex 492 nm; λem 518 nm in ethanol

application(s)

cell analysis

storage temp.

2-8°C

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Application

Dextran labeled with fluorescein isothiocyanate for possible use in perfusion studies in animals.
Fluorescein isothiocyanate–dextran (FITC-Dextran 70) is use as a fluorescent probe to study cell processes such as cell permeability, phagocytosis and endocytosis and to study mechanisms of biomolecular delivery. FITC-Dextran 70 may be used to study the capacity, selectivity and efficiency of encapsulation and release by drug delivery vehicles.

Other Notes

Internalisation of FITC and FITC-dextran by suspension cultured plant cells[1]; In the study of fluid pinocytosis in leukocytes[2]

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Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315 - H319 - H335

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
BCCM6019
BCCM2312
BCCL1732
BCCK1124
BCCH0026

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Louise Coppin et al.
Cells, 8(8) (2019-08-10)
The efficacy of mesenchymal stem cell infusion is currently tested in numerous clinical trials. However, therapy-induced thrombotic consequences have been reported in several patients. The aim of this study was to optimize protocols for heterologous human adult liver-derived progenitor cell
Chuan He et al.
FEBS letters, 587(3), 285-290 (2012-12-25)
We have successfully delivered FITC and FITC-Dextran (70, 250 kDa) into canola protoplasts by centrifuging cells with different amounts of microbubbles at variable centrifuge speed. The efficiency is around 90%, while cell viability remains high. Confocal microscopy images show that
Stefanie Wöhl-Bruhn et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 81(3), 573-581 (2012-05-15)
Hydrogels are promising delivery systems for the controlled release of biomacromolecules. Based on previous studies, hydrogels were prepared from crosslinkable hydroxyethyl starch with new linker groups to improve mechanical and release properties of the resulting hydrogels. Polyethylene glycol methacrylate with
Guangxiang Zang et al.
BMC cancer, 15, 234-234 (2015-04-18)
Shb is a signaling protein downstream of vascular endothelial growth factor receptor-2 and Shb deficiency has been found to restrict tumor angiogenesis. The present study was performed in order to assess metastasis in Shb deficiency using B16F10 melanoma cells. B16F10
L. Cole et al.
Journal of Cell Science, 96, 721-721 (1990)
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Questions

  1. Is this product fixable?

    1 answer

    1. Yes, paraformaldehyde can be used to fix cells. In normal circumstances, formaldehyde is a cross-linking fixative that is used to fix protein and DNA.

      Looking at formaldehyde fixation, the following are applicable:
      Formaldehyde cross-links with the amino group of the N-terminal amino acid residue and the side chains of 12:
      Arginine
      Cysteine
      Histidine
      Lysine
      Depending on the peptide sequence, methylol groups, Schiff-bases, and methylene bridges were form

      Please note that although the term paraformaldehyde is used, paraformaldehyde exists only as a solid. Once the bonds of the polymer are broken, solutions contain only formaldehyde. Any paraformaldehyde in the solution would simply be an undissolved precipitate at the bottom of the solution.

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