917419

2-(2-(Piperidin-4-yl)phenyl)ethan-1-amine dihydrochloride

• Synonym(s): Semi-flexible linker for PROTAC^® development
• Empirical Formula (Hill Notation): C₁₃H₂₂Cl₂N₂
• Molecular Weight: 277.23
• MDL number: MFCD32864224
• UNSPSC Code: 12352116
• NACRES: NA.22

Properties

• form: powder
• Quality Level: 100
• reaction suitability: reagent type: linker
• functional group: amine
• storage temp.: 2-8°C
• SMILES string: NCCC1=C(C=CC=C1)C2CCNCC2.Cl.Cl
• InChI: 1S/C13H20N2.2ClH/c14-8-5-11-3-1-2-4-13(11)12-6-9-15-10-7-12;;/h1-4,12,15H,5-10,14H2;2*1H
• InChI key: ONRWENIJVYXDCE-UHFFFAOYSA-N

Description

Application

2-(2-(Piperidin-4-yl)phenyl)ethan-1-amine dihydrochloride is a 4-aryl piperidine useful as a semi-flexible linker in PROTAC development for targeted protein degradation. Incorporation of rigidity into the linker region of bifunctional protein degraders may impact the 3D orientation of the degrader and thus ternary complex formation as well as optimization of drug-like properties.

Other Notes

Portal: Building PROTAC^® Degraders for Targeted Protein Degradation

Crosslinkers for Bioconjugation

Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation

Legal Information

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable