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Sigma-Aldrich

PAL-NovaPEG resin

Novabiochem®

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About This Item

UNSPSC Code:
51171641
NACRES:
NA.22

Quality Level

200

product line

NovaPEG
Novabiochem®

form

beads

reaction suitability

reaction type: Fmoc solid-phase peptide synthesis

manufacturer/tradename

Novabiochem®

application(s)

peptide synthesis

functional group

amine

storage temp.

2-8°C

General description

PAL-NovaPEG resin consists of Barany′s aminomethyl-dimethoxyphenoxyvaleric acid linker [1] attached to NovaPEG amino resin. The amino group of this linker can be easily acylated under standard coupling conditions. Following peptide assembly, treatment with 95% TFA containing scavengers releases the desired peptide amide. Studies have shown the acid sensitivity of this linker to be around twice that of the Rink amide linker [2].

Associated Protocols and Technical Articles
Protocols for Loading of Peptide Synthesis Resins

Analysis Note

Color (visual): white to yellow to beige/brown to orange
Appearance of substance (visual): beads
Loading (Photometric determination of the Fmoc-chromophore liberated upon treatment with DBU/DMF): 0.30 - 0.70 mmol/g
Swelling Volume (in DMF): lot specific result

Legal Information

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

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Articles

Fmoc SPPS Linkers

Novabiochem® offers a wide range of linkers and derivatized resins for Fmoc solid-phase peptide synthesis with specialized protocols.

Protocols

Peptide Resin Loading Protocols

Review various resins like Merrifield, trityl-based, and hydroxymethyl-functionalized for peptide immobilization for diverse applications.

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

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