OK to freeze desiccated (hygroscopic) protect from light
shipped in
wet ice
storage temp.
2-8°C
General description
A potent broad-spectrum hydroxamic acid inhibitor of matrix metalloproteinases (MMPs). Inhibits MMPs in vitro [Ki = 0.4 nM for skin fibroblast collagenase (MMP-1); Ki = 0.5 nM for gelatinase A (MMP-2); Ki = 27 nM for stromelysin (MMP-3); Ki = 0.1 nM for neutrophil collagenase (MMP-8); and Ki = 0.2 nM for gelatinase B (MMP-9)]. Also prevents the release of TNF-α in vivo and in vitro and abrogates endotoxin-induced lethality in mice.
Biochem/physiol Actions
Cell permeable: yes
Primary Target MMP-1
Product does not compete with ATP.
Reversible: no
Target Ki: 400 pM for MMP-1; 500 pM for MMP-2; 27 nM for MMP-3; 100 pM for MMP-8; and 200 pM for MMP-9
Packaging
Packaged under inert gas
Warning
Toxicity: Irritant (B)
Physical form
A 10 mM (1 mg/257 µl) solution of GM6001 (Cat. No. 364205) in DMSO.
Reconstitution
Following initial use, aliquot and refrigerate (4°C).
Other Notes
Solorzano, C.C., et al. 1997. Shock7, 427. Galardy, R.E., et al. 1994. Ann. NY Acad. Sci.732, 315. Galardy, R.E., et al. 1994. Cancer Res.54, 4715. Galardy, R.E., et al. 1993. Drugs Future18, 1109. Grobelny, D., et al. 1992. Biochemistry31, 7152.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class Code
10 - Combustible liquids
WGK
WGK 2
Flash Point(F)
188.6 °F - closed cup - (Dimethylsulfoxide)
Flash Point(C)
87 °C - closed cup - (Dimethylsulfoxide)
Certificates of Analysis (COA)
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Immunology and cell biology, 87(6), 489-495 (2009-05-13)
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Cancer cells function as primary architects of the tumor microenvironment. However, the molecular features of cancer cells that govern stromal cell phenotypes remain unclear. Here, we show that cancer-associated fibroblast (CAF) heterogeneity is driven by lung adenocarcinoma (LUAD) cells at
Cellular senescence and the senescence-associated secretory phenotype (SASP) are implicated in aging and age-related disease, and SASP-related inflammation is thought to contribute to tissue dysfunction in aging and diseased animals. However, whether and how SASP factors influence the regenerative capacity
Select different protease inhibitor types based on your needs to prevent protein degradation during isolation and characterization and safeguard proteins in sample prep.
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