1.06370

Sodium dihydrogen phosphate

anhydrous 99.99 Suprapur^®

• Synonym(s): Sodium dihydrogen phosphate, Sodium biphosphate
• Empirical Formula (Hill Notation): H₂NaO₄P
• CAS Number: 7558-80-7
• Molecular Weight: 119.98
• MDL number: MFCD00003527
• UNSPSC Code: 12352302
• EC Index Number: 231-449-2
• NACRES: NA.21

Properties

• grade: for inorganic trace analysis
• Quality Level: 100
• Assay: 99.99%
• form: crystals
• potency: 8290 mg/kg LD₅₀, oral (Rat); >7940 mg/kg LD₅₀, skin (Rabbit)
• pH: 4.5 (20 °C, 10 g/L in H₂O)
• mp: >450 °C ((> 842 °F))
• solubility: 850 g/L
• bulk density: 940 kg/m³
• anion traces: chloride (Cl^-): ≤5 ppm; sulfate (SO₄^2-): ≤30 ppm
• cation traces: As: ≤0.05 ppm; Ba: ≤10.0 ppm; Ca: ≤0.50 ppm; Cd: ≤0.010 ppm; Ce: ≤0.010 ppm; Co: ≤0.010 ppm; Cs: ≤5 ppm; Cu: ≤0.010 ppm; Eu: ≤0.010 ppm; Fe: ≤0.05 ppm; Hg: ≤0.05 ppm; K: ≤5.0 ppm; La: ≤0.010 ppm; Li: ≤1.0 ppm; Mg: ≤0.50 ppm; Mn: ≤0.010 ppm; N: ≤10 ppm; Ni: ≤0.010 ppm; Pb: ≤0.010 ppm; Rb: ≤5.0 ppm; Sm: ≤0.010 ppm; Sr: ≤0.50 ppm; Tl: ≤0.01 ppm; Y: ≤0.010 ppm; Yb: ≤0.010 ppm; Zn: ≤0.010 ppm
• storage temp.: 2-30°C
• InChI: 1S/Na.H3O4P/c;1-5(2,3)4/h;(H3,1,2,3,4)/q+1;/p-1
• InChI key: AJPJDKMHJJGVTQ-UHFFFAOYSA-M

Description

Application

• Development of a multiparticulate drug delivery system for in situ amorphisation.: This study explores the creation of a multiparticulate drug delivery system using sodium dihydrogen phosphate to induce in situ amorphisation, enhancing the bioavailability of poorly water-soluble drugs (Holm et al., 2022).

Analysis Note

Purity (metallic): ≥ 99.99 %
Assay (acidimetric): ≥ 99.0 %
Spec. Absorbance A at 260 nm (2 cm; 10 %): ≤ 0.020
Chloride (Cl): ≤ 5 ppm
Sulfate (SO₄): ≤ 30 ppm
Total nitrogen (N): ≤ 10 ppm
As (Arsenic): ≤ 0.05 ppm
Ba (Barium): ≤ 10.0 ppm
Ca (Calcium): ≤ 0.50 ppm
Cd (Cadmium): ≤ 0.010 ppm
Ce (Cerium): ≤ 0.010 ppm
Co (Cobalt): ≤ 0.010 ppm
Cs (Cesium): ≤ 5 ppm
Cu (Copper): ≤ 0.010 ppm
Eu (Europium): ≤ 0.010 ppm
Fe (Iron): ≤ 0.05 ppm
Hg (Mercury): ≤ 0.05 ppm
K (Potassium): ≤ 5.0 ppm
La (Lanthanum): ≤ 0.010 ppm
Li (Lithium): ≤ 1.0 ppm
Mg (Magnesium): ≤ 0.50 ppm
Mn (Manganese): ≤ 0.010 ppm
Ni (Nickel): ≤ 0.010 ppm
Pb (Lead): ≤ 0.010 ppm
Rb (Rubidium): ≤ 5.0 ppm
Sm (Samarium): ≤ 0.010 ppm
Sr (Strontium): ≤ 0.50 ppm
Tl (Thallium): ≤ 0.01 ppm
Y (Yttrium): ≤ 0.010 ppm
Yb (Ytterbium): ≤ 0.010 ppm
Zn (Zinc): ≤ 0.010 ppm

Legal Information

SUPRAPUR is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class Code: 13 - Non Combustible Solids
• WGK: WGK 1
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable