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Key Documents

D167800

Sigma-Aldrich

2,3-Dimethylmaleic anhydride

98%

Synonym(s):

Dimethylmaleic anhydride

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About This Item

Empirical Formula (Hill Notation):
C6H6O3
CAS Number:
Molecular Weight:
126.11
Beilstein:
112044
EC Number:
MDL number:
UNSPSC Code:
12162002
PubChem Substance ID:
NACRES:
NA.23

Assay

98%

form

flakes

bp

223 °C (lit.)

mp

93-96 °C (lit.)

SMILES string

CC1=C(C)C(=O)OC1=O

InChI

1S/C6H6O3/c1-3-4(2)6(8)9-5(3)7/h1-2H3

InChI key

MFGALGYVFGDXIX-UHFFFAOYSA-N

Application

Reagent used in the synthesis of maleimides[1] and as an amino group protecting agent for superoxide dismutase.[2]

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Precautionary Statements

Hazard Classifications

Acute Tox. 4 Oral

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Se Rim Yoon et al.
Journal of biomedical materials research. Part A, 100(8), 2027-2033 (2012-05-15)
A charge-converting and pH-dependent nanocarrier was achieved by conjugating 2,3-dimethylmaleic anhydride (DMMA) to the amino group of an octadecyl grafted poly (2-hydroxyethyl aspartamide) (PHEA-g-C(18)-NH(2)) backbone, thereby forming a spherical micelle. PHEA, a poly(amino acid)s derivative, was derived from poly(succinimide), which
Kabrambam D Singh et al.
Scientific reports, 7(1), 12483-12483 (2017-10-04)
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S Tsunoda et al.
The Journal of pharmacology and experimental therapeutics, 290(1), 368-372 (1999-06-25)
We attempted to develop a novel method for the chemical modification of cytokines with synthetic polymers to increase in vivo therapeutic efficacy. A pH-reversible amino-protective reagent, dimethylmaleic anhydride (DMMAn), was used for polymer conjugation of tumor necrosis factor-alpha (TNF-alpha) with
Hyeong Sup Yu et al.
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As caterpillars detect the presence of predators and secrete poison, herein, we show an innovative and highly effective cancer therapeutic system using biocompatible chitosan nanofiber (CNf) installed with a pH-responsive motif that senses tumor extracellular pH, pHe, prior to delivering
J. Controlled Release, 28, 203-203 (1994)

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