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Sigma-Aldrich

6-Ethoxy-2-benzothiazolesulfonamide

97%

Synonym(s):

6-Ethoxyzolamide, Ethoxzolamide

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About This Item

Empirical Formula (Hill Notation):
C9H10N2O3S2
CAS Number:
452-35-7
Molecular Weight:
258.32
EC Number:
207-199-5
MDL number:
MFCD00057089
UNSPSC Code:
12352100
PubChem Substance ID:
24860121
NACRES:
NA.22

Assay

97%

form

solid

mp

190-193 °C (lit.)

SMILES string

CCOc1ccc2nc(sc2c1)S(N)(=O)=O

InChI

1S/C9H10N2O3S2/c1-2-14-6-3-4-7-8(5-6)15-9(11-7)16(10,12)13/h3-5H,2H2,1H3,(H2,10,12,13)

InChI key

OUZWUKMCLIBBOG-UHFFFAOYSA-N

Gene Information

human ... CA1(759) , CA12(771) , CA13(377677) , CA14(23632) , CA2(760) , CA3(761) , CA4(762) , CA5A(763) , CA5B(11238) , CA6(765) , CA7(766) , CA9(768)
mouse ... Car5a(12352)

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General description

6-Ethoxy-2-benzothiazolesulfonamide is a membrane permeable carbonic anhydrase inhibitor and its ocular disposition and pharmacology in normal albino rabbits has been investigated. It causes inhibition of insulin degradation in vitro.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315,H319,H335

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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Larissa A Shimoda et al.
American journal of physiology. Lung cellular and molecular physiology, 292(4), L1002-L1012 (2007-01-09)
Hypoxic pulmonary vasoconstriction (HPV) occurs with ascent to high altitude and can contribute to development of high altitude pulmonary edema (HAPE). Vascular smooth muscle contains carbonic anhydrase (CA), and acetazolamide (AZ), a CA inhibitor, blunts HPV and might be useful
T H Maren et al.
Experimental eye research, 55(1), 73-79 (1992-07-01)
We have measured sequentially the concentrations of ethoxzolamide (6-ethoxybenzothiazole-2-sulfonamide) in ocular tissues following its intravenous or topical administration to normal albino rabbits. This was done in parallel with determinations of intraocular pressure (IOP) measured by tonometer or direct manometry. Ethoxzolamide
Gaspar Peña-Münzenmayer et al.
Pflugers Archiv : European journal of physiology, 466(7), 1317-1327 (2013-10-02)
TASK-2 is a K2P K(+) channel considered as a candidate to mediate CO2 sensing in central chemosensory neurons in mouse. Neuroepithelial cells in zebrafish gills sense CO2 levels through an unidentified K2P K(+) channel. We have now obtained zfTASK-2 from
Matthias C Jecklin et al.
Journal of molecular recognition : JMR, 22(4), 319-329 (2009-04-18)
We performed a systematic comparison of three label-free methods for quantitative assessment of binding strengths of proteins interacting with small molecule ligands. The performance of (1) nanoelectrospray ionization mass spectrometry (nESI-MS), (2) surface plasmon resonance (SPR), and (3) isothermal titration
Basel H Abuaita et al.
Infection and immunity, 77(9), 4111-4120 (2009-07-01)
Vibrio cholerae is a gram-negative bacterium that is the causative agent of cholera, a severe diarrheal illness. The two biotypes of V. cholerae O1 capable of causing cholera, classical and El Tor, require different in vitro growth conditions for induction
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