284548

3,4-(Methylenedioxy)toluene

97%

• Synonym(s): 5-Methyl-1,3-benzodioxole
• Empirical Formula (Hill Notation): C₈H₈O₂
• CAS Number: 7145-99-5
• Molecular Weight: 136.15
• MDL number: MFCD00005833
• UNSPSC Code: 12352100
• PubChem Substance ID: 24857165
• NACRES: NA.22

Properties

• Assay: 97%
• form: liquid
• refractive index: n20/D 1.532 (lit.)
• bp: 199-200 °C (lit.)
• density: 1.135 g/mL at 25 °C (lit.)
• SMILES string: Cc1ccc2OCOc2c1
• InChI: 1S/C8H8O2/c1-6-2-3-7-8(4-6)10-5-9-7/h2-4H,5H2,1H3
• InChI key: GHPODDMCSOYWNE-UHFFFAOYSA-N

Description

Application

3,4-(Methylenedioxy)toluene can be used as a cation scavenger for the selective cleavage of 4-(3,4-dimethoxyphenyl)benzyl (DMPBn) ethers affording the corresponding deprotected products in the presence of trifluoroacetic acid (TFA) in anhydrous CH₂Cl₂.
It can also be used as a starting material to prepare:

• 1,3-Benzodioxole-5-carboxaldehyde via photooxidation using CBr₄.
• 6-Methyl-1,3-benzodioxole-5-carboxaldehyde by treating with dichloromethylmethyl ether and TiCl₄.

Safety Information

• Pictograms: GHS05,GHS07
• Signal Word: Danger
• Hazard Statements: H302,H318
• Precautionary Statements: P264 - P270 - P280 - P301 + P312 - P305 + P351 + P338 - P501
• Hazard Classifications: Acute Tox. 4 Oral - Eye Dam. 1
• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 3
• Flash Point(F): 168.8 °F - closed cup
• Flash Point(C): 76 °C - closed cup
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves