119725

4′-Piperidinoacetophenone

97%

• Synonym(s): 1-[4-(1-Piperidinyl)]phenyl]ethanone
• Empirical Formula (Hill Notation): C₁₃H₁₇NO
• CAS Number: 10342-85-5
• Molecular Weight: 203.28
• EC Number: 233-746-2
• MDL number: MFCD00006481
• UNSPSC Code: 12352100
• PubChem Substance ID: 24847298
• NACRES: NA.22

Properties

• Assay: 97%
• mp: 85-87 °C (lit.)
• functional group: ketone
• SMILES string: CC(=O)c1ccc(cc1)N2CCCCC2
• InChI: 1S/C13H17NO/c1-11(15)12-5-7-13(8-6-12)14-9-3-2-4-10-14/h5-8H,2-4,9-10H2,1H3
• InChI key: JCMZZYSPSGHBNM-UHFFFAOYSA-N

Description

General description

4′-Piperidinoacetophenone undergoes Claisen-Schmidt condensation with substituted benzaldehydes using NaOH-Al₂O₃ by microwave irradiation to give chalcones. It has antimycobacterial activity.

Application

4′-Piperidinoacetophenone was used as internal standard in the determination of pethidine, a narcotic analgesic drug in body fluids by gas chromatography-tandem mass spectrometry.

Pharmacological activity:

• Selective antimycobacterial activity
• Bronchodilator compound
• Modulation of flagellar motility in Chlamydomonas

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H315,H319,H335
• Precautionary Statements: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Target Organs: Respiratory system
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves