MAP2K3
mitogen-activated protein kinase kinase 3
Synonyms:
MAPKK3, MEK3, MKK3, PRKMK3, SAPKK-2, SAPKK2
Species:
Human MAP2K3 (5606), Mouse Map2k3 (26397), Rat Map2k3 (303200), cow MAP2K3 (516039), domestic cat MAP2K3 (101082274), sheep MAP2K3 (101122959), Horse MAP2K3 (100053481), domestic guinea pig Map2k3 (100726100), chicken MAP2K3 (416496), dog MAP2K3 (489547)
UniProtKB ID:
Gene ID:
- Human(5606) Summary: The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is activated by mitogenic and environmental stress, and participates in the MAP kinase-mediated signaling cascade. It phosphorylates and thus activates MAPK14/p38-MAPK. This kinase can be activated by insulin, and is necessary for the expression of glucose transporter. Expression of RAS oncogene is found to result in the accumulation of the active form of this kinase, which thus leads to the constitutive activation of MAPK14, and confers oncogenic transformation of primary cells. The inhibition of this kinase is involved in the pathogenesis of Yersina pseudotuberculosis. Multiple alternatively spliced transcript variants that encode distinct isoforms have been reported for this gene. [provided by RefSeq, Jul 2008]
- Mouse(26397) mitogen-activated protein kinase kinase 3
- Rat(303200) mitogen activated protein kinase kinase 3
- cow(516039) mitogen-activated protein kinase kinase 3
- domestic cat(101082274) mitogen-activated protein kinase kinase 3
- sheep(101122959) mitogen-activated protein kinase kinase 3
- Horse(100053481) mitogen-activated protein kinase kinase 3
- domestic guinea pig(100726100) mitogen-activated protein kinase kinase 3
- chicken(416496) mitogen-activated protein kinase kinase 3
- dog(489547) mitogen-activated protein kinase kinase 3
- naked mole-rat(101718318) mitogen-activated protein kinase kinase 3
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-phospho-MAP2K3 (pThr222) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human
Application
immunohistochemistry
western blot
western blot
Anti-MEK3/MEK6 Antibody, clone 8R1J5, Rabbit Monoclonal, ,
Species Reactivity
human, rat
Application
western blot
Anti-MEK3 antibody produced in rabbit, ,
Species Reactivity
human, mouse, rat
Application
immunohistochemistry
western blot
western blot
Anti-MKK3/MKK6 Antibody, clone 2E21 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Species Reactivity
human, mouse, rat
Application
immunocytochemistry
immunohistochemistry
western blot
immunohistochemistry
western blot
Small Molecule - Inhibitor
Product Number
Description
Species