SAB4501762
Anti-HSL antibody produced in rabbit
affinity isolated antibody
Synonym(s):
Hormone sensitive lipase, LIPE, LIPS
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About This Item
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biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 116 kDa
species reactivity
human, mouse, rat
concentration
~1 mg/mL
technique(s)
ELISA: 1:1000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... LIPE(3991)
General description
Human hormone-sensitive lipase (HSL) gene, containing 9 exons and spanning ~11kB, is mapped to chromosome 19q13.3. HSL is majorly expressed in adipose and steroidogenic tissues, but expressed at low levels in heart and skeletal muscle, macrophages, and islets. Functional HSL exists as a homodimer with high hydrolytic activity. HSL is characterized with a C-terminal catalytic domain, regulatory module and an N-terminal domain responsible for protein–protein and protein–lipid interactions.
Immunogen
The antiserum was produced against synthesized peptide derived from human HSL.
Immunogen Range: 520-569
Immunogen Range: 520-569
Biochem/physiol Actions
Hormone-sensitive lipase (HSL) is the major source of energy for most of the tissues. It plays a vital role in hydrolysis of triacylglycerol stored in adipose tissue and possibly steroidogenesis. HSL activity is regulated through reversible phosphorylation by catecholamines and insulin. HSL, also hydrolyzes cholesterol esters in the adrenals, ovaries, testes, and macrophages and plays an essential role in spermatogenesis. HSL mRNA expressed in islets might be implicated in glucose-induced insulin secretion. Abnormality in the protein expression results in obesity, atherosclerosis and type II diabetes.
Features and Benefits
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Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
WGK
nwg
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Stephen J Yeaman
The Biochemical journal, 379(Pt 1), 11-22 (2004-01-17)
Although described initially as an intracellular adipocyte-specific triacylglycerol lipase, it is now clear that HSL (hormone-sensitive lipase) is expressed in multiple tissues and plays a number of roles in lipid metabolism, including that of a neutral cholesteryl ester hydrolase. The
C Holm et al.
Science (New York, N.Y.), 241(4872), 1503-1506 (1988-09-16)
Hormone-sensitive lipase, a key enzyme in fatty acid mobilization, overall energy homeostasis, and possibly steroidogenesis, is acutely controlled through reversible phosphorylation by catecholamines and insulin. The 757-amino acid sequence predicted from a cloned rat adipocyte complementary DNA showed no homology
J Osuga et al.
Proceedings of the National Academy of Sciences of the United States of America, 97(2), 787-792 (2000-01-19)
Hormone-sensitive lipase (HSL) is known to mediate the hydrolysis not only of triacylglycerol stored in adipose tissue but also of cholesterol esters in the adrenals, ovaries, testes, and macrophages. To elucidate its precise role in the development of obesity and
Wucai Yang et al.
Scientific reports, 7(1), 15080-15080 (2017-11-10)
Melatonin (N-acetyl-5-methoxytryptamine) is a derivative of tryptophan which is produced and secreted mainly by the pineal gland and regulates a variety of important central and peripheral actions. To examine the potential effects of melatonin on the proliferation and differentiation of
Fredric B Kraemer et al.
Journal of lipid research, 43(10), 1585-1594 (2002-10-05)
Hormone-sensitive lipase (HSL) is an intracellular neutral lipase that is capable of hydrolyzing triacylglycerols, diacylglycerols, monoacylglycerols, and cholesteryl esters, as well as other lipid and water soluble substrates. HSL activity is regulated post-translationally by phosphorylation and also by pretranslational mechanisms.
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