SAB4301399

Anti-phospho-DRP1 (pSer⁶³⁷) antibody produced in rabbit

affinity isolated antibody

• Synonym(s): DLP1, DNM1L, DRP1, DVLP, Dymple
• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: rabbit
• Quality Level: 100
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• mol wt: 82 kDa
• species reactivity: human
• concentration: 1.0 mg/mL
• technique(s): western blot: 1:500-1:1000 (Cell Lysate)
• isotype: IgG
• accession no.: NP_036192.2.
• UniProt accession no.: O00429
• shipped in: wet ice
• storage temp.: −20°C
• target post-translational modification: phosphorylation (pSer637)
• Gene Information: human ... DNM1L(10059)

Description

General description

Dynamin related protein 1 (DRP1) is a dynamin-related guanosine triphosphatase. The gene is located on human chromosome 12p11.21. DRP1 is a cytosolic protein, which is also present on the outer mitochondrial membrane.

Specificity

The antibody detects endogenous levels of DRP1 only when phosphorylated at serine 637.

Immunogen

Peptide sequence around phosphorylation site of Serine637(K-L-S(p)-A-R) derived from Human DRP1.

Application

Anti-phospho-DRP1 (pSer⁶³⁷) antibody produced in rabbit has been used in immunoblotting and western blotting.

Biochem/physiol Actions

Dynamin related protein 1 (DRP1) is an important regulator of mitochondrial fission and peroxisomal division. It regulates proper mitochondrial function, apoptosis and necrosis. Mutations in this gene is associated with Alzheimer′s disease.

Features and Benefits

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Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 1
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable