109185

Saccharin

≥98%

• Synonym(s): 2,3-Dihydroxy-1,2-benzisothiazol-3-one-1,1-dioxide, 2-Sulfobenzoic acid imide, o-Benzoic sulfimide
• Empirical Formula (Hill Notation): C₇H₅NO₃S
• CAS Number: 81-07-2
• Molecular Weight: 183.18
• Beilstein: 6888
• EC Number: 201-321-0
• MDL number: MFCD00005866
• UNSPSC Code: 12352100
• PubChem Substance ID: 24846892
• NACRES: NA.22

Properties

• Quality Level: 100
• Assay: ≥98%
• mp: 226-229 °C (lit.)
• solubility: H₂O: soluble 1g in 290ml; acetone: soluble 1g in 12ml; alcohol: soluble 1g in 31ml; boiling water: soluble 1g in 25ml; glycerol: soluble 1g in 50ml; alcohol: very slightly soluble; chloroform: slightly soluble; diethyl ether: slightly soluble
• SMILES string: O=C1NS(=O)(=O)c2ccccc12
• InChI: 1S/C7H5NO3S/c9-7-5-3-1-2-4-6(5)12(10,11)8-7/h1-4H,(H,8,9)
• InChI key: CVHZOJJKTDOEJC-UHFFFAOYSA-N

Description

Application

Saccharin was used in high performance liquid chromatographic method for the simultaneous separation and determination of acesulfame potassium, saccharine and aspartame. It was used in sweet preference test of rats.

Biochem/physiol Actions

Dietery administration of saccharin after N-methyl-N′-nitro-N-nitrosoguanidine promotes tumor development in rats.

A sweet tastant for mammals. A glycerol taste receptor binding site specific for glucose has been proposed in drosophila.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 2
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves