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Key Documents

SAB5702771

Sigma-Aldrich

Anti-CDK8 Antibody, clone 7L5X2, Rabbit Monoclonal

Synonym(s):

K35

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.46

Pricing and availability is not currently available.

biological source

rabbit

Quality Level

material

colorless

clone

7L5X2, monoclonal

form

liquid

mol wt

55 kDa

species reactivity

human, rat, rat

concentration

0.8 mg/mL

technique(s)

western blot: 1:500 - 1:2000

color

colorless

General description

This gene encodes a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are known to be important regulators of cell cycle progression. This kinase and its regulatory subunit, cyclin C, are components of the Mediator transcriptional regulatory complex, involved in both transcriptional activation and repression by phosphorylation of the carboxy-terminal domain of the largest subunit of RNA polymerase II. This kinase regulates transcription by targeting the cyclin-dependent kinase 7 subunits of the general transcription initiation factor IIH, thus providing a link between the Mediator complex and the basal transcription machinery. Multiple pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2016]

Immunogen

A synthetic peptide corresponding to a sequence within amino acids 1-100 of human CDK8 (P49336).
PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.

Application

WB

Storage Class Code

10 - Combustible liquids

WGK

WGK 1


Certificates of Analysis (COA)

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