S1542

Anti-Substance P antibody produced in rabbit

whole antiserum

• Synonym(s): Anti-SP
• MDL number: MFCD00162870
• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: rabbit
• conjugate: unconjugated
• antibody form: whole antiserum
• antibody product type: primary antibodies
• clone: polyclonal
• contains: 15 mM sodium azide
• species reactivity: human, pig, bovine, rat, cat, monkey
• technique(s): dot blot: 1:20,000; radioimmunoassay: 1:5,000
• UniProt accession no.: P20366
• shipped in: dry ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... TAC1(6863) ; rat ... Tac1(24806)

Description

General description

Substance P (SP) is a 11 amino acid peptide. It is a member of tachykinins family, that includes neurokinin A, neurokinin B, neuropeptide K, neuropeptide Y and hemokinin-1 It is located on human chromosome 7q21.3.

Substance P (SP) is widely distributed throughout the central nervous system (CNS) and peripheral nervous system, including the brain, spinal cord, primary sensory neurons and intrinsic nerve fibers associated with the gastrointestinal (GI) tract.

Immunogen

synthetic Substance P (SP), conugated to KLH.

Application

Anti-Substance P antibody has been used in immunostaining and immunohistochemistry.

Biochem/physiol Actions

Substance P (SP) improves the multiplication and paracrine ability of stem cells acquired from adipose in vitro. It participates in the movement of several organ tracts, trigger glandular secretion and controls autonomic reflexes. It plays an important role in neuroimmune and systemic autoimmune/inflammatory conditions like multiple sclerosis (MS), rheumatoid arthritis, inflammatory bowel disease and also in infections and cancer.

Substance P (SP) is a neurotransmitter or neuromodulator. SP mediates the process of neurogenic inflammation.

Analysis Note

The antiserum is evaluated for activity and specificity by dot blot immunoassay and RIA.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable