I0899

Imipramine hydrochloride

BioXtra, ≥99% (TLC)

• Synonym(s): 10,11-Dihydro-N,N-dimethyl-5H-dibenz[b,f]azepine-5-propanamine hydrochloride, 5-[3-(Dimethylamino)propyl]-10,11-dihydro-5H-dibenz[b,f]azepine hydrochloride
• Empirical Formula (Hill Notation): C₁₉H₂₄N₂ · HCl
• CAS Number: 113-52-0
• Molecular Weight: 316.87
• EC Number: 204-030-7
• MDL number: MFCD00012669
• UNSPSC Code: 12352116
• PubChem Substance ID: 24895912
• NACRES: NA.25

Properties

• product line: BioXtra
• Assay: ≥99% (TLC)
• form: powder
• impurities: ≤0.0005% Phosphorus (P); ≤0.1% Insoluble matter
• ign. residue: ≤0.1%
• solubility: H₂O: 50 mg/mL, colorless to faintly yellow
• anion traces: sulfate (SO₄^2-): ≤0.05%
• cation traces: Al: ≤0.0005%; Ca: ≤0.005%; Cu: ≤0.0005%; Fe: ≤0.005%; K: ≤0.005%; Mg: ≤0.0005%; NH₄⁺: ≤0.05%; Na: ≤0.005%; Pb: ≤0.001%; Zn: ≤0.0005%
• SMILES string: Cl[H].CN(C)CCCN1c2ccccc2CCc3ccccc13
• InChI: 1S/C19H24N2.ClH/c1-20(2)14-7-15-21-18-10-5-3-8-16(18)12-13-17-9-4-6-11-19(17)21;/h3-6,8-11H,7,12-15H2,1-2H3;1H
• InChI key: XZZXIYZZBJDEEP-UHFFFAOYSA-N
• Gene Information: human ... SLC6A2(6530) , SLC6A4(6532)

Description

Application

• Novel, fast, and reliable electrochemical dsDNA biosensor based on O-terminated pristine nanocrystalline boron-doped diamond electrode for DNA interaction studies.: Research featuring a novel electrochemical dsDNA biosensor that facilitates the study of DNA interactions with imipramine hydrochloride, enhancing our understanding of its genotoxic effects and providing crucial insights for biochemistry applications (Augustín M et al., 2024).


• Comparison of two pharmacological protocols for inducing ex copula ejaculation in donkeys.: In this comparative study, imipramine hydrochloride is used within a pharmacological protocol, offering significant insights into veterinary applications and animal reproductive studies (Khan FA et al., 2024).


• Development of Visible Spectrophotometric Methods for the Determination of Tricyclic Antidepressants Based on Formation of Molecular Complexes with p-Benzoquinones.: This publication outlines a novel spectrophotometric method for analyzing tricyclic antidepressants like imipramine hydrochloride, providing an efficient tool for quantitative analysis in pharmaceutical and clinical research (Ciuca MD et al., 2023).

Biochem/physiol Actions

Tricyclic antidepressant; inhibits the serotonin and norepinephrine transporters with K_is of 7.7 nM and 67 nM, respectively. Has little effect on the dopamine transporter (K_i = 25 μM).

Safety Information

• Pictograms: GHS06
• Signal Word: Danger
• Hazard Statements: H300
• Precautionary Statements: P264 - P270 - P301 + P310 - P405 - P501
• Hazard Classifications: Acute Tox. 2 Oral
• Storage Class Code: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• WGK: WGK 1
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable