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Key Documents

G5171

Sigma-Aldrich

Anti-Granulocyte Colony Stimulating Factor antibody produced in goat

IgG fraction of antiserum, lyophilized powder

Synonym(s):

Anti-G-CSF

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About This Item

MDL number:
UNSPSC Code:
51111800
NACRES:
NA.41

biological source

goat

conjugate

unconjugated

antibody form

IgG fraction of antiserum

antibody product type

primary antibodies

clone

polyclonal

form

lyophilized powder

species reactivity

human

technique(s)

neutralization: suitable
western blot: 1-2 μg/mL

UniProt accession no.

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... CSF3(1440)

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General description

Mature myeloid cells are derived from bone-marrow derived precursor cells by the activity of three colony stimulating factors, granulocyte/macrophage colony-stimulating factor (GM-CSF), macrophage colony-stimulating factor (M-CSF) and granulocyte colony-stimulating factor (G-CSF). The expression of G-CSF is the result of activation of pathways in response to tumor necrosis factor-α, LPS and toll-like receptor ligands. The pathways that induce the effects of G-CSF are PI3K, ERK1/2 and p38. The generation of neutrophils and induction of the circulation of hematopoietic stem cells from the bone marrow are the main functions of G-CSF. There are additional activities attributed to G-CSF such as neuroprotection, immunomodulation and generation of cardiac cells and dendritic cells. Large quantities of G-CSF are secreted in a variety of myeloid and non-myeloid cancers and rheumatoid arthritis
Monoclonal anti-granulocyte colony stimulating factor recognizes human G-CSF.

Immunogen

purified, recombinant human granulocyte colony stimulating factor, expressed in E. coli.

Application

Anti-granulocyte colony stimulating factor antibody may be used for immunoblotting at a working concentration of 1-2 μg/ml. The antibody is also suitable for neutralization assays.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline.

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Storage Class Code

13 - Non Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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