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460R-1

Sigma-Aldrich

Heat Shock Protein 70 (EP377) Rabbit Monoclonal Primary Antibody

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About This Item

UNSPSC Code:
12352203

biological source

rabbit

Quality Level

100
500

conjugate

unconjugated

antibody form

culture supernatant

antibody product type

primary antibodies

clone

EP377, monoclonal

description

For In Vitro Diagnostic Use in Select Regions

form

buffered aqueous solution

species reactivity

human

packaging

vial of 0.1 mL concentrate (460R-14)
vial of 0.1 mL concentrate Research Use Only (460R-14-RUO)
vial of 0.5 mL concentrate (460R-15)
vial of 1.0 mL concentrate (460R-16)
vial of 1.0 mL concentrate Research Use Only (460R-16-RUO)
vial of 1.0 mL pre-dilute Research Use Only (460R-17-RUO)
vial of 1.0 mL pre-dilute ready-to-use (460R-17)
vial of 7.0 mL pre-dilute ready-to-use (460R-18)
vial of 7.0 mL pre-dilute ready-to-use Research Use Only (460R-18-RUO)

manufacturer/tradename

Cell Marque™

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:100 (concentrated)

isotype

IgG

control

hepatocellular carcinoma

shipped in

wet ice

storage temp.

2-8°C

visualization

cytoplasmic, nuclear

Gene Information

human ... HSPA1A(3303)

Related Categories

General description

The Heat Shock Protein 70 family of highly conserved chaperone proteins increase in expression upon exposure to stress factors such as temperature shock, hypoxia, oxidative stress, and pH change. This promotes cell survival by repairing misfolded proteins and preventing protein aggregates, among other functions. Likewise, tumor cells can use this mechanism to confer a survival advantage as demonstrated in Heat Shock Protein 70 overexpression in hepatocellular carcinoma.

Quality

United States - IVD
European Union - IVD
Japan - RUO

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.

Preparation Note

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Other Notes

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Legal Information

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany

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Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 2

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Maureen E Murphy
Carcinogenesis, 34(6), 1181-1188 (2013-04-09)
The HSP70 family of heat shock proteins consists of molecular chaperones of approximately 70kDa in size that serve critical roles in protein homeostasis. These adenosine triphosphatases unfold misfolded or denatured proteins and can keep these proteins in an unfolded, folding-competent
Eun Shin et al.
Journal of hepato-biliary-pancreatic sciences, 18(4), 544-550 (2011-01-15)
Heat shock protein 70 (HSP70) and glutamine synthetase (GS) have been proposed to be promising markers for the differentiation of malignant and benign hepatocellular lesions. The aim of this study was to investigate the clinicopathological significance of the expression of
Luca Di Tommaso et al.
Journal of hepatology, 50(4), 746-754 (2009-02-24)
Liver biopsy for hepatocellular carcinoma (HCC) detection is largely restricted to small hepatocellular lesions, which are often morphologically challenging, requiring careful distinction between dysplastic nodules (high-grade) and well-differentiated HCC. We investigated the diagnostic accuracy of a panel of markers (HSP70
Stephen M Lagana et al.
Applied immunohistochemistry & molecular morphology : AIMM, 21(2), 170-176 (2012-08-24)
The pathologic distinction between hepatocellular carcinoma (HCC) and hepatocellular adenoma (HCA) is sometimes problematic due to histologic overlap between the 2 entities, a problem amplified on small biopsy specimens. Several recently characterized immunohistochemical markers such as glypican-3 (GPC-3), heat-shock protein-70
Thuy B Nguyen et al.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 29(3), 283-292 (2016-01-16)
Well-differentiated hepatocellular carcinoma can mimic high-grade dysplastic nodule in cirrhotic liver and hepatocellular adenoma in non-cirrhotic liver. This study evaluates the efficacy of combined use of heat-shock protein 70 (HSP70), glutamine synthetase (GS) and glypican-3 in this setting. Immunohistochemistry for

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