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Y0000635

Modafinil

European Pharmacopoeia (EP) Reference Standard

Synonym(s):

2-[(Diphenylmethyl)sulfinyl]­acetamide

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About This Item

Empirical Formula (Hill Notation):
C15H15NO2S
CAS Number:
68693-11-8
Molecular Weight:
273.35
MDL number:
MFCD00868082
UNSPSC Code:
41116107
PubChem Substance ID:
329831065
NACRES:
NA.24

grade

pharmaceutical primary standard

API family

modafinil

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

SMILES string

NC(=O)CS(=O)C(c1ccccc1)c2ccccc2

InChI

1S/C15H15NO2S/c16-14(17)11-19(18)15(12-7-3-1-4-8-12)13-9-5-2-6-10-13/h1-10,15H,11H2,(H2,16,17)

InChI key

YFGHCGITMMYXAQ-UHFFFAOYSA-N

Gene Information

human ... SLC6A3(6531)

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General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Modafinil EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Biochem/physiol Actions

Modafinil is a central nervous system vigilance promoting agent, which posseses neuroprotective properties.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

Pictograms

Health hazardExclamation mark
GHS08,GHS07

Signal Word

Warning

Hazard Statements

H302,H361d

Hazard Classifications

Acute Tox. 4 Oral - Repr. 2

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number

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Derek Dunn et al.
Chemical biology & drug design, 81(3), 433-435 (2012-12-05)
Utilizing atypical wake-promoting agent modafinil (inactive in both rH(3) and hH(3) binding assays) as a launching pad, a series of sulfinyl- and sulfone-derived H(3) receptor inverse agonists were developed. Brain-permeable compound 27, a potent member of the series displayed excellent
Trends in on-label and off-label modafinil use in a nationally representative sample.
Renée A Peñaloza et al.
JAMA internal medicine, 173(8), 704-706 (2013-04-05)
Mariana Raineri et al.
PloS one, 7(10), e46599-e46599 (2012-10-12)
Methamphetamine is a drug of abuse that can cause neurotoxic damage in humans and animals. Modafinil, a wake-promoting compound approved for the treatment of sleeping disorders, is being prescribed off label for the treatment of methamphetamine dependence. The aim of
Arterial hypertension and resistance to antihypertensive treatment: a new adverse drug reaction with modafinil.
Jacques Amar et al.
Therapie, 68(1), 53-54 (2013-03-15)
Jordy van Enkhuizen et al.
Psychopharmacology, 225(3), 661-674 (2012-09-05)
The Iowa Gambling Task (IGT) can be used to quantify impulsive and risky choice behaviors in psychiatric patients, e.g., bipolar disorder (BD) sufferers. Although developing treatments for these behaviors is important, few predictive animal models exist. Inhibition of the dopamine
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