B91005

tert-Butyl carbazate

98%, for peptide synthesis

• Synonym(s): tert-Butoxycarbonyl hydrazide, Boc-hydrazide
• Linear Formula: (CH₃)₃COCONHNH₂
• CAS Number: 870-46-2
• Molecular Weight: 132.16
• Beilstein: 1756967
• EC Number: 212-795-3
• MDL number: MFCD00007593
• UNSPSC Code: 12352108
• PubChem Substance ID: 24892122
• NACRES: NA.22

Properties

• product name: tert-Butyl carbazate, 98%
• Assay: 98%
• form: crystals
• bp: 63-65 °C/0.1 mmHg (lit.)
• mp: 39-42 °C (lit.)
• application(s): peptide synthesis
• SMILES string: O=C(NN)OC(C)(C)C
• InChI: 1S/C5H12N2O2/c1-5(2,3)9-4(8)7-6/h6H2,1-3H3,(H,7,8)
• InChI key: DKACXUFSLUYRFU-UHFFFAOYSA-N

Description

Application

Employed in a palladium-catalyzed cross-coupling with vinyl halides leading to N-Boc-N-alkenylhydrazines.
Reagent used in solid phase peptide synthesis and in α-amino aldehyde optical purity determinations. Condenses with aldehydes to form hydrazones which are intermediates in the synthesis of HIV-1 protease inhibitors.

Safety Information

• Pictograms: GHS02
• Signal Word: Danger
• Hazard Statements: H228
• Precautionary Statements: P210
• Hazard Classifications: Flam. Sol. 1
• Storage Class Code: 4.1B - Flammable solid hazardous materials
• WGK: WGK 3
• Flash Point(F): 195.8 °F
• Flash Point(C): 91 °C
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves