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SML2082

Sigma-Aldrich

Scrambled 10Panx1 trifluoroacetate salt

≥98% (HPLC)

Synonym(s):

10PanxSCR TFA, FSVYWAQADR TFA, L-phenylalanyl-L-seryl-L-valyl-L-tyrosyl-L-tryptophyl-L-alanyl-L-glutaminyl-L-alanyl-L-a-aspartyl-L-arginine TFA, Phe-Ser-Val-Tyr-Trp-Ala-Gln-Ala-Asp-Arg TFA, SCPanx, TFA, Scrambled 10Panx TFA

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About This Item

Empirical Formula (Hill Notation):
C58H79N15O16 · xC2HF3O2
CAS Number:
1315378-72-3
Molecular Weight:
1242.34 (free base basis)
UNSPSC Code:
12352200
NACRES:
NA.77

Assay

≥98% (HPLC)

form

film (Colorless)

color

white to off-white

shipped in

wet ice

storage temp.

−20°C

InChI

1S/C58H79N15O16/c1-29(2)47(73-55(86)44(28-74)72-50(81)37(59)23-32-11-6-5-7-12-32)56(87)71-41(24-33-16-18-35(75)19-17-33)53(84)70-42(25-34-27-64-38-14-9-8-13-36(34)38)52(83)66-30(3)48(79)67-39(20-21-45(60)76)51(82)65-31(4)49(80)69-43(26-46(77)78)54(85)68-40(57(88)89)15-10-22-63-58(61)62/h5-9,11-14,16-19,27,29-31,37,39-44,47,64,74-75H,10,15,20-26,28,59H2,1-4H3,(H2,60,76)(H,65,82)(H,66,83)(H,67,79)(H,68,85)(H,69,80)(H,70,84)(H,71,87)(H,72,81)(H,73,86)(H,77,78)(H,88,89)(H4,61,62,63)

InChI key

VNQGVHMGXBRHRA-UHFFFAOYSA-N

Biochem/physiol Actions

SCPanx (10PanxSCR) corresponds to the scrambled version of the pannexin-1 (panx1) inhibitor peptide 10panx1 and serves as a negative control peptide in pannexin-1 inhibitory studies involving 10panx1 treatment both in vitro and in vivo.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

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Pannexin1 (Panx1) channels are large high conductance channels found in all vertebrates that can be activated under several physiological and pathological conditions. Our published data indicate that HIV infection results in the extended opening of Panx1 channels (5-60 min), allowing
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