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SCP0020

Sigma-Aldrich

[Sar1]-Angiotensin II

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About This Item

Empirical Formula (Hill Notation):
C49H71N13O10
Molecular Weight:
1002.17
UNSPSC Code:
12352209
NACRES:
NA.32

Assay

≥95% (HPLC)

form

lyophilized

composition

Peptide Content, ≥65%

storage condition

protect from light

storage temp.

−20°C

Amino Acid Sequence

Sar-Arg-Val-Tyr-Ile-His-Pro-Phe

Application

Angiotensins are peptide hormone components of the renin-angiotensin system involved in the regulation of blood vessel constriction and aldosterone release. Angiotensin I, a decapeptide derived from angiotensinogen, is a converted to Angiotensin II by the removal of the two C-terminal amino acids. Various analogues of Angiotensins I and II made by amino acid substitution are used in structure and sequence studies to analyze and differentiate the functions of natural angiotensins.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Vani X Oliveira et al.
Regulatory peptides, 172(1-3), 1-7 (2011-07-27)
Angiotensin II (AII) is the active octapeptide product of the renin enzymatic cascade, which is responsible for sustaining blood pressure. In an attempt to establish the AII-receptor-bound conformation of this octapeptide, we designed conformationally constrained analogues by scanning the entire
Kar Neng Lai et al.
Contributions to nephrology, 170, 135-144 (2011-06-11)
Diabetic nephropathy (DN) is a leading cause of end-stage renal disease in developed countries where type 2 diabetes mellitus has reached epidemic proportions. Although the exact pathogenesis of DN is not fully understood and is likely diverse in nature, there
Novel concept in the mechanism of injury and protection of gastric mucosa: role of Renin-Angiotensin system and active metabolites of Angiotensin.
Brzozowski T, Ptak-Belowska A, et al.
Current Medicinal Chemistry, 16, 55-62 (2012)
Mauricio Sendeski et al.
Radiology, 251(3), 697-704 (2009-04-16)
To determine whether a type of contrast medium (CM), iodixanol, modifies outer medullary descending vasa recta (DVR) vasoreactivity and nitric oxide (NO) production in isolated microperfused DVR. Animal handling conformed to the Animal Care Committee Guidelines of all participating institutions.

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