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BMY 7378 dihydrochloride

Name: BMY 7378 dihydrochloride
Brand: SIGMA

≥98% (HPLC), solid

Synonym(s):

8-[2-[4-(2-Methoxyphenyl)-1-piperazinyl]ethyl]-8-azaspiro[4.5]decane-7,9-dione dihydrochloride

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About This Item

Empirical Formula (Hill Notation):

C₂₂H₃₁N₃O₃ · 2HCl

CAS Number:

21102-95-4

Molecular Weight:

458.42

NACRES:

NA.77

PubChem Substance ID:

24278080

UNSPSC Code:

12352200

MDL number:

MFCD00153771

Assay:

≥98% (HPLC)

Form:

solid

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Properties

assay

≥98% (HPLC)

form

solid

color

white

solubility

H₂O: >5 mg/mL

SMILES string

Cl.Cl.COc1ccccc1N2CCN(CC2)CCN3C(=O)CC4(CCCC4)CC3=O

InChI

1S/C22H31N3O3.2ClH/c1-28-19-7-3-2-6-18(19)24-13-10-23(11-14-24)12-15-25-20(26)16-22(17-21(25)27)8-4-5-9-22;;/h2-3,6-7H,4-5,8-17H2,1H3;2*1H

InChI key

NIBOMXUDFLRHRV-UHFFFAOYSA-N

Gene Information

human ... ADRA1D(146), HTR1A(3350)

Description

Biochem/physiol Actions

BMY 7378 dihydrochloride is a partial 5-HT_1A serotonin receptor agonist and selective α_1D-adrenoceptor antagonist.

Features and Benefits

This compound is featured on the α1-Adrenoceptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Legal Information

Manufactured and sold with the permission of Bristol Myers Squibb Corporation.

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This Item	L9908	B7148	SML2714
Sigma-Aldrich B134 BMY 7378 dihydrochloride	Sigma-Aldrich L9908 LY-294,002 hydrochloride	Sigma-Aldrich B7148 Buspirone hydrochloride	Sigma-Aldrich SML2714 VU0155072
description ≥98% (HPLC), solid	description solid, ≥98% (HPLC)	description -	description ≥98% (HPLC)
assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay -	assay ≥98% (HPLC)
form solid	form solid	form powder	form powder
solubility H₂O: >5 mg/mL	solubility H₂O: insoluble, DMSO: >5 mg/mL	solubility -	solubility DMSO: 2 mg/mL, clear
color white	color white to off-white	color -	color white to beige
Gene Information human ... ADRA1D(146), HTR1A(3350)	Gene Information -	Gene Information human ... HTR1A(3350)	Gene Information -

Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

PPE (personal protective equipment)

Eyeshields, Gloves, type N95 (US)

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