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SMB00119

Sigma-Aldrich

Arjunolic acid

≥95% (LC/MS-ELSD)

Synonym(s):

2,3,23-Trihydroxyolean-12-en-28-oic acid

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About This Item

Empirical Formula (Hill Notation):
C30H48O5
CAS Number:
465-00-9
Molecular Weight:
488.70
MDL number:
MFCD11113458
UNSPSC Code:
12352205
PubChem Substance ID:
329824797
NACRES:
NA.25

Quality Level

200

Assay

≥95% (LC/MS-ELSD)

form

solid

application(s)

metabolomics
vitamins, nutraceuticals, and natural products

storage temp.

−20°C

SMILES string

CC1(C)CC[C@@]2(CC[C@]3(C)C(=CC[C@@H]4[C@@]5(C)C[C@@H](O)[C@H](O)[C@@](C)(CO)[C@@H]5CC[C@@]34C)[C@@H]2C1)C(O)=O

InChI

1S/C30H48O5/c1-25(2)11-13-30(24(34)35)14-12-28(5)18(19(30)15-25)7-8-22-26(3)16-20(32)23(33)27(4,17-31)21(26)9-10-29(22,28)6/h7,19-23,31-33H,8-17H2,1-6H3,(H,34,35)/t19-,20+,21+,22+,23-,26-,27-,28+,29+,30-/m0/s1

InChI key

RWNHLTKFBKYDOJ-DDHMHSPCSA-N

Related Categories

General description

Natural product derived from plant source.

Biochem/physiol Actions

Arjunolic acid (AA) is a triterpenoid saponin that has known anti-oxidant activity. AA has also shown promise in against type 1 diabetes through its prevention of hyperglycemia induced activation of MAPKs, PKC, NF-kB signaling cascades. Arjunolic acid is beneficial in protecting again acetaminophen (APAP)-induced liver and hepatocyte injury.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Prasenjit Manna et al.
Biochimie, 94(3), 786-797 (2011-12-14)
Vascular inflammation and cardiac dysfunction are the leading causes of mortality and morbidity among the diabetic patients. Type 1 diabetic mellitus (T1DM) is associated with increased cardiovascular complications at an early stage of the disease. The purpose of the present
Jyotirmoy Ghosh et al.
Toxicology in vitro : an international journal published in association with BIBRA, 22(8), 1918-1926 (2008-10-11)
The present study was conducted to investigate the role of arjunolic acid (AA) against sodium fluoride (NaF)-induced cytotoxicity and necrotic cell death in murine hepatocytes. Dose-dependent studies suggest that incubation of hepatocytes with NaF (100mM) for 1h significantly decreased the
Prasenjit Manna et al.
Chemico-biological interactions, 170(3), 187-200 (2007-09-15)
Arsenic is a well-established environmental toxin, which damages various organs of the body. A triterpenoid saponin, arjunolic acid (AA) has been isolated from the bark of Terminalia arjuna. The present study was conducted to investigate the preventive role of AA
Prasenjit Manna et al.
Toxicology and applied pharmacology, 244(2), 114-129 (2010-01-08)
Present study investigates the beneficial role of arjunolic acid (AA) against the alteration in the cytokine levels and simultaneous activation of oxidative stress responsive signaling pathways in spleen under hyperglycemic condition. Diabetes was induced by injection of streptozotocin (STZ) (at
Prasenjit Manna et al.
Free radical research, 46(7), 815-830 (2012-04-11)
In this review article, we describe the most recent development of the beneficial effect of arjunolic acid (AA) in reducing type 1 diabetic pathophysiology. Diabetic mellitus is a serious and growing health problem worldwide. Increasing evidence suggest that oxidative stress
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