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S6635

Sigma-Aldrich

Span® 20

greener alternative

Synonym(s):

Sorbitan laurate, Sorbitan monolaurate

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About This Item

CAS Number:
1338-39-2
EC Number:
215-663-3
MDL number:
MFCD00005365
UNSPSC Code:
12161900
PubChem Substance ID:
24899716
NACRES:
NA.25
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description

non-ionic

Quality Level

200

mol wt

346.47 g/mol

greener alternative product characteristics

Use of Renewable Feedstocks
Learn more about the Principles of Green Chemistry.

sustainability

Greener Alternative Product

concentration

≥44% (GC)

greener alternative category

, Aligned

SMILES string

CCCCCCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O

InChI

1S/C18H34O6/c1-2-3-4-5-6-7-8-9-10-11-16(21)23-13-15(20)18-17(22)14(19)12-24-18/h14-15,17-20,22H,2-13H2,1H3/t14-,15?,17+,18+/m0/s1

InChI key

LWZFANDGMFTDAV-WYDSMHRWSA-N

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General description

Span 20 is a co-surfactant. [1]
We are committed to bringing you Greener Alternative Products, which adhere to one or more of The 12 Principles of Green Chemistry. This product is 100% bio-based non-ionic surfactant, thus aligns with "Use of Renewable Feedstocks" and belongs to "12 principles aligned" category of our greener alternatives.

Application

Span 20 has been used in a study to assess enhanced solubility and oral bioavailability of itraconazole. [2] It has also been used in a study to investigate the oxidation of unsaturated lipids in oil-in-water emulsions. [1]

Other Notes

Fatty acid composition: Lauric acid (C12:0) ≥ 44%; balance primarily myristic (C14:0), palmitic (C16:0) and linolenic (C18:3) acids.

Legal Information

Span is a registered trademark of Croda International PLC

Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

>300.2 °F - closed cup

Flash Point(C)

> 149 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
0000250318
0000250318
MKCS3076
MKCS6729
MKCQ4315

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Claire Berton et al.
Journal of colloid and interface science, 377(1), 244-250 (2012-04-25)
The development of lipid oxidation in oil-in-water (O/W) emulsions is widely influenced by the properties of the interfacial layer, which separates the oil and water phases. In this work, the effect of the structure of the interface on the oxidative
Yuji Komizu et al.
Bioorganic & medicinal chemistry letters, 21(13), 3962-3965 (2011-06-03)
Markedly inhibitory effects of hybrid liposomes (HL-n) composed of 90 mol% L-α-dimyristoylphosphatidylcholine (DMPC) and 10 mol% polyoxyethylene(n) dodecyl ethers on the growth of adult T-cell leukemia cells were obtained for the first time. It is noteworthy that HL-n could selectively
Pao-Chu Wu et al.
Drug development and industrial pharmacy, 36(12), 1398-1403 (2010-06-16)
Nicardipine hydrochloride has been used widely for the treatment of angina pectoris and hypertension. Because of its extensive first pass metabolism after oral administration, the transdermal administration of nicardipine microemulsions was developed in this study. Microemulsions consisted of isopropyl myristate
Sinead Hickey et al.
International journal of pharmaceutics, 388(1-2), 213-222 (2009-12-17)
High-resolution ultrasonic spectroscopy was applied to analyse a pseudo-ternary phase diagram for a mixture consisting of water/ethyl oleate/Tween 80 and Span 20 at 25 degrees C. The measured changes in the ultrasonic velocity and attenuation with concentration of water in
Muhammad Moniruzzaman et al.
Chemical communications (Cambridge, England), 46(9), 1452-1454 (2010-02-18)
We report the first successful application of a novel IL-assisted non-aqueous microemulsion stabilized by a blend of two nontoxic surfactants, polyoxyethylene sorbitan monooleate (Tween-80), and sorbitan laurate (Span-20) for transdermal delivery of acyclovir, which is insoluble or sparingly soluble in
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Questions

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  1. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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  2. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

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