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RAB0820

Sigma-Aldrich

Mouse Lepr / Leptin Receptor ELISA Kit

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About This Item

UNSPSC Code:
41116158
NACRES:
NA.32

species reactivity

mouse

packaging

kit of 96 wells (12 strips x 8 wells)

technique(s)

ELISA: suitable

input

sample type cell culture supernatant(s)
sample type serum
sample type plasma

assay range

inter-assay cv: <12%
intra-assay cv: <10%
sensitivity: 32 pg/mL
standard curve range: 32.77-8000 pg/mL

detection method

colorimetric

shipped in

wet ice

storage temp.

−20°C

Gene Information

mouse ... Lepr(16847)

General description

The antibody pair provided in this kit recognizes mouse Leptin Receptor.

Application

For research use only. Not for use in diagnostic procedures.
Please refer to the attached General ELISA KIT Procedure (sandwich, competitive & Indirect ELISA)

Biochem/physiol Actions

Leptin receptor (Lepr) belonging to class I cytokine receptor family, binds with leptin, a small non-glycosylated peptide hormone and transduces signal. Lepr expression is present in brain and immune cells. Signal transduction through Lepr regulates fat metabolism in mammals. Lepr is part of the hematopoietic pathway. Lepr is a marker for mesenchymal stem/stromal cells (MSCs) and regulates the regenerative process of bone and cartilage after injury. Lepr regulates pancreatic β cell functions. Polymorphism in Lepr causes metabolic diseases like obesity, dyslipidemia, hypertension and Type 2 diabetes. Mutations in Lepr associates with polycystic ovarian syndrome (PCOS) susceptibility.

Kit Components Also Available Separately

Product No.
Description
SDS
  • RABTMB3ELISA Colorimetric TMB Reagent (HRP Substrate, Item H)SDS
  • RABSTOP3ELISA Stop Solution (Item I)SDS
  • RABWASH420X Wash Buffer (Item B)SDS

Pictograms

Corrosion
GHS05

Signal Word

Warning

Hazard Statements

H290

Precautionary Statements

P234 - P390

Hazard Classifications

Met. Corr. 1

Storage Class Code

8A - Combustible corrosive hazardous materials

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Plasma soluble leptin receptor levels are associated with pancreatic beta-cell dysfunction in patients with type 2 diabetes
Morioka T, et al.
Journal of diabetes investigation, 9(1), 55-62 (2018)
Leptin receptor makes its mark on MSCs
Matsuzaki Y, et al.
Cell Stem Cell, 15(2), 112-114 (2014)
LEPR gene polymorphism and plasma soluble leptin receptor levels are associated with polycystic ovary syndrome in Han Chinese women
Tu X, et al.
Personalized Medicine, 14(4), 299-307 (2017)
Leptin and leptin receptors in salivary glands of primary Sjogren?s syndrome
Erbasan F, et al.
Pathology Research and Practice, 212(11), 1010-1014 (2016)
A role for leptin and its cognate receptor in hematopoiesis
Bennett BD, et al.
Current Biology, 6(9), 1170-1180 (1996)

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