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MAK108

Sigma-Aldrich

PLTP Activity Assay Kit

Supplied by Roar Biomedical, Inc.

Synonym(s):

Phospholipid transfer protein activity assay kit

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About This Item

UNSPSC Code:
12161503
NACRES:
NA.84

usage

sufficient for 100 fluorometric tests

application(s)

pharmaceutical

detection method

fluorometric

relevant disease(s)

cardiovascular diseases

storage temp.

2-8°C

Gene Information

human ... PLTP(5360)

General description

Phospholipid transfer protein (PLTP) is a protein present in normal human plasma. PLTP transfers phospholipids among lipoproteins in plasma.

Suitability

Suitable to determine Phospholipid transfer protein (PLTP) activity in plasma or serum (fresh or frozen) as well as other sources of PLTP.

Principle

The PLTP Activity Assay Kit includes proprietary substrates to detect PLTP mediated transfer of fluorescent substrate. Transfer activity results in increased fluorescent emission intensity (λEx = 465 nm/λEm = 535 nm) from the assay.

Storage Class Code

10 - Combustible liquids


Certificates of Analysis (COA)

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Ryan J Henderson et al.
Drug development and industrial pharmacy, 35(9), 1139-1146 (2009-04-22)
To investigate how different formulations of Amphotericin-B (Amp-B) affect the activity of phospholipid transfer protein (PLTP) when incubated with hyperlipidemic and normolipidemic plasma at physiological temperature (37 degrees C). Six hyperlipidemic and six normolipidemic plasma samples were collected and tested
Axel Schlitt et al.
American journal of nephrology, 27(2), 138-143 (2007-02-20)
Phospholipid transfer protein (PLTP) is mainly involved in high-density lipoprotein (HDL) metabolism. The role of PLTP in atherogenesis is still controversial. We aimed to investigate PLTP activity in hemodialysis (HD) patients, a population which has an increased risk for the
Marta Marchesi et al.
British journal of pharmacology, 164(5), 1460-1468 (2011-04-14)
Besides a significant reduction of low-density lipoprotein (LDL) cholesterol, statins moderately increase high-density lipoprotein (HDL) levels. In vitro studies have indicated that this effect may be the result of an increased expression of apolipoprotein (apo)A-I, the main protein component of
Alexander C Reisinger et al.
Frontiers in cell and developmental biology, 9, 795460-795460 (2022-01-25)
Background: High-density lipoproteins (HDL) are thought to play a protective role in sepsis through several mechanisms, such as promotion of steroid synthesis, clearing bacterial toxins, protection of the endothelial barrier, and antioxidant/inflammatory activities. However, HDL levels decline rapidly during sepsis
Alexis Klein et al.
Arteriosclerosis, thrombosis, and vascular biology, 26(9), 2160-2167 (2006-07-11)
The aim of the present study was to assess the effect of alpha-tocopherol, the main vitamin E isomer on phosphatidylserine (PS) exposure at the surface of circulating erythrocytes, and to determine consequences on erythrocyte properties. In vitro alpha-tocopherol enrichment of

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