I1010
IgA from human colostrum
reagent grade, ≥95%, essentially salt-free, lyophilized powder
Synonym(s):
Human IgA
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About This Item
Recommended Products
conjugate
unconjugated
Quality Level
grade
reagent grade
Assay
≥95%
form
essentially salt-free, lyophilized powder
storage temp.
2-8°C
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General description
IgA antibody is secretory antibody and is present abundantly in mucous linings of gastrointestinal, respiratory and genitourinary tracts, tears, colostrum and saliva. Thus secretory IgA contributes to the humoral defense mechanism against the pathogens on mucosal surfaces
Human IgA is purified from pooled normal human colostrum by fractionation and ion-exchange fractionation.
Human IgA is purified from pooled normal human colostrum by fractionation and ion-exchange fractionation.
Application
Purified IgA may be used as a reference antigen, standard, blocking agent or coating protein in a variety of immunoassays including ELISA, dot immunobinding, immunoblotting, immunodiffusion and immunoelectrophoresis. Other applications include starting materials for the preparation of immunogens and solidphase immunoadsorbents. IgA from human colostrum was used as a standard in ELISA (1 mg/ml) and gel electrophoresis.
Reconstitution
Reconstitute with buffered saline (150 mM sodium chloride).
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage Class Code
13 - Non Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
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Proceedings of the National Academy of Sciences of the United States of America, 111(37), 13463-13468 (2014-08-30)
IgA is the most prevalent antibody type on mucosal surfaces and the second most prevalent antibody in circulation, yet its role in immune defense is not fully understood. Here we show that IgA is carried inside cells during virus infection
EClinicalMedicine, 27, 100561-100561 (2020-10-13)
Norovirus (NV) causes acute gastroenteritis in infants. Humoral and fecal immunoglobulin A (IgA) responses have been correlated with protection against NV; however, the role of breast milk IgA against NV infection and associated diarrhea is still unknown. This study aimed
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Mucosa-associated lymphoid tissue (MALT) specifically protects mucosal surfaces. In a previous study of the human conjunctiva, evidence was also found for the presence of MALT in the lacrimal sac. The present study, therefore, aims to investigate its morphology and topographical
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Little is known about the impact of nutrition on toddler gut microbiota. The plasticity of the toddler gut microbiota indicates that nutritional modulation beyond infancy could potentially impact its maturation. The objective of this study was to determine the effect
Maternal health, neonatology and perinatology, 5, 9-9 (2019-06-18)
Colostrum is the primary source of maternal immunoglobulin A (IgA) for the newborn. IgA participates in protection and regulation mechanisms of the immune response at the neonate's mucosa. Several studies have evaluated infectious diseases and vaccine protocols effects during pregnancy
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