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Key Documents

D0444

Sigma-Aldrich

DT-2 trifluoroacetate salt

≥95% (HPLC), film

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About This Item

Empirical Formula (Hill Notation):
C122H223N53O23 · xC2HF3O2
Molecular Weight:
2800.42 (free base basis)
UNSPSC Code:
12352200
NACRES:
NA.77

Quality Level

200

Assay

≥95% (HPLC)

form

film

composition

Peptide content, ≥60%

color

colorless to white

solubility

H2O: 0.5 mg/mL, clear

shipped in

wet ice

storage temp.

−20°C

Amino Acid Sequence

Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Pro-Pro-Leu-Arg-Lys-Lys-Lys-Lys-Lys-His-NH2

Biochem/physiol Actions

Cell permeable cGMP protein kinase (PKG) inhibitor

Features and Benefits

This compound is featured on the PKA & PKG page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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W R Dostmann et al.
Proceedings of the National Academy of Sciences of the United States of America, 97(26), 14772-14777 (2000-12-20)
Arrays of octameric peptide libraries on cellulose paper were screened by using (32)P-autophosphorylated cGMP-dependent protein kinase Ialpha (cGPK) to identify peptide sequences with high binding affinity for cGPK. Iterative deconvolution of every amino acid position in the peptides identified the
Mark S Taylor et al.
Molecular pharmacology, 65(5), 1111-1119 (2004-04-23)
Cyclic GMP-dependent protein kinase (PKG) serves as an important physiological regulator of vascular reactivity and tone. However, available inhibitors of PKG have exhibited variable effects in intact tissue, hindering the elucidation of the functional role of PKG in blood vessels.
Christin Christensen et al.
Stem cells and development, 15(5), 647-654 (2006-11-16)
Previously, we have shown that increasing the intracellular cGMP concentration enhances the sonic hedgehog (Shh) response in neural plate cells. The use of two mouse embryonic stem (ES) cell lines allowed a highly sensitive and reproducible quantification of the Shh

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PKA & PKG

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PKA & PKG

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PKA & PKG

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PKA & PKG

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