C239

CNQX disodium salt hydrate

≥98% (HPLC), solid, AMPA/kainate receptor antagonist.

• Synonym(s): 6-Cyano-7-nitroquinoxaline-2,3-dione disodium salt hydrate
• Empirical Formula (Hill Notation): C₉H₂N₄Na₂O₄ · xH₂O
• CAS Number: 115066-14-3
• Molecular Weight: 276.12 (anhydrous basis)
• MDL number: MFCD09953908
• UNSPSC Code: 12352200
• PubChem Substance ID: 24277972
• NACRES: NA.77

Properties

• product name: CNQX disodium salt hydrate, ≥98% (HPLC), solid
• Quality Level: 100
• Assay: ≥98% (HPLC)
• form: solid
• storage condition: protect from light
• color: orange to red
• solubility: H₂O: >2 mg/mL (warmed)
• SMILES string: O.[Na+].[Na+].[O-]c1nc2cc(C#N)c(cc2nc1[O-])[N+]([O-])=O
• InChI: 1S/C9H4N4O4.2Na.H2O/c10-3-4-1-5-6(2-7(4)13(16)17)12-9(15)8(14)11-5;;;/h1-2H,(H,11,14)(H,12,15);;;1H2/q;2*+1;/p-2
• InChI key: LCDWHGXMFAZHEO-UHFFFAOYSA-L
• Gene Information: human ... ADORA1(134) , ADORA2A(135) , ADORA2B(136) , ADORA3(140) , GRIA1(2890) , GRIA2(2891) , GRIA3(2892) , GRIA4(2893)

Description

Application

CNQX disodium salt hydrate has been used as:

• as a competitive non-NMDA receptor antagonist and competitive AMPA/kainate receptor antagonist in neuronal cultures(110)
• as a glutamatergic blockers for measuring inhibitory postsynaptic currents in projection neurons(111)
• as a AMPA glutamate receptor antagonist prefrontal cortex neurons(112)

Biochem/physiol Actions

CNQX(6-cyano-7-nitroquinoxaline-2,3-dioneis) is a potent, competitive AMPA/kainate receptor antagonist. It is a quinoxaline derivative and also an antagonist for non-N-methyl-d-aspartate (non-NMDA) glutamate receptor. CNQX mediates depolarization thalamic reticular nucleus via α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptors (AMPARs). It displays micromolar affinity towards AMPA/kainate receptor.

Potent, competitive AMPA/kainate receptor antagonist.

Features and Benefits

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Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves