30290

Cytidine 5′-diphosphocholine sodium salt hydrate

≥99.0% (HPLC)

• Synonym(s): CDP-choline-Na
• Empirical Formula (Hill Notation): C₁₄H₂₅N₄NaO₁₁P₂ · xH₂O
• CAS Number: 33818-15-4
• Molecular Weight: 510.31 (anhydrous basis)
• Beilstein: 4110040
• MDL number: MFCD00150508
• UNSPSC Code: 41106305
• PubChem Substance ID: 57648419
• NACRES: NA.51

Properties

• biological source: synthetic
• Quality Level: 100
• Assay: ≥99.0% (HPLC)
• form: powder
• impurities: ≤8% water
• storage temp.: 2-8°C
• SMILES string: [Na+].C[N+](C)(C)CCOP([O-])(=O)OP([O-])(=O)OCC1OC([C@H](O)[C@@H]1O)N2C=CC(N)=NC2=O
• InChI: 1S/C14H26N4O11P2.Na/c1-18(2,3)6-7-26-30(22,23)29-31(24,25)27-8-9-11(19)12(20)13(28-9)17-5-4-10(15)16-14(17)21;/h4-5,9,11-13,19-20H,6-8H2,1-3H3,(H3-,15,16,21,22,23,24,25);/q;+1/p-1/t9?,11-,12-,13?;/m1./s1
• InChI key: YWAFNFGRBBBSPD-MBWJOHGMSA-M

Description

Application

Cytidine 5′-diphosphocholine (CDP-choline) is generated by choline-phosphate cytidylyltransferase EC 2.7.7.15 in support of the synthesis of phosphatidylcholine. CDP-choline is being used in studies of its affects on neurorecovery.

Cytidine 5′-diphosphocholine sodium salt hydrate has been used as a component of the mixture during the ribonucleotide reductase (RNR) assay in mouse primary pancreatic acinar cells.

Biochem/physiol Actions

Cytidine 5′-diphosphocholine (CDP-choline) is an endogenous compound that plays an important role in the synthesis of phospholipids in the cell membrane. It acts as a choline donor for the biosynthesis of acetylcholine and phosphatidylcholine, a neuronal membrane phospholipid. CDP-choline enhances brain metabolism and influences the levels of various neurotransmitters including dopamine, epinephrine, and acetylcholine. It has been studied as a neuroprotectant after cerebral ischemia. CDP-choline is observed to exhibit therapeutic effects against cognitive impairment arising from multiple causes, cerebral vascular diseases, after-head trauma, and Alzheimer′s disease.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves