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SMB00971

Sigma-Aldrich

4-Ethylphenol sodium sulfate

Synonym(s):

4-Ethylphenyl sulfate sodium salt

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About This Item

Empirical Formula (Hill Notation):
C8H9NaO4S
Molecular Weight:
224.21
NACRES:
NA.77

Assay

≥98.0% (HPLC)

Quality Level

form

solid

storage temp.

−20°C

General description

4-Ethylphenol sodium sulfate is the sodium salt of 4-Ethylphenyl sulfate (4EPS). 4-Ethylphenyl sulfate is a gut microbial metabolite derived from tyrosine, which is converted into 4-ethylphenol and subsequently sulfated in the liver. Upregulated urine 4EPS levels are found among rats prone to insulin resistance and obesity. Increased plasma 4EPS was reported in a murine model of autism, and mice treated with 4EPS displayed anxiety-like behaviours. Higher levels of 4-ethylphenylsulfate were also found in plasma, liver, heart and kidneys in a rat model of chronic kidney disease. 4EPS is a component of the urine of male rats, and both 4-ethylphenyl sulfate and 4-ethylphenol are thought to participate in pheromonal communication. p-Cresol-sulfate and 4-ethylphenyl sulfate are thought to derive from tyrosine and have similar bioactivities, however their enzymatic production may differ.

Application

Metabolomics research
Microbiome research

Other Notes

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Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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S Achiraman et al.
Journal of biosciences, 27(7), 679-686 (2003-02-07)
The present study was carried out to investigate the chemical nature of the urine of male mice and to assess its bioactivity. Urine of mature male mice was extracted with dichloromethane (1 : 1 ratio v/v) and analysed by gas-chromatography
Thomas J Velenosi et al.
Scientific reports, 6, 22526-22526 (2016-03-05)
Chronic kidney disease (CKD) results in the accumulation of metabolic waste products that are normally cleared by the kidney, known as uremia. Many of these waste products are from bacteria metabolites in the gut. Accumulation of uremic toxins in plasma
Alexandra Lafaye et al.
Journal of mass spectrometry : JMS, 39(6), 655-664 (2004-07-06)
This paper reports a liquid chromatographic/electrospray ionization mass spectrometric (LC/ESI-MS) method for profiling a wide range of structurally different sulfoconjugated compounds in urine and its application to the characterization of biomarkers for heavy metal toxicity in rat urine. Sulfoconjugates were
Elaine Y Hsiao et al.
Cell, 155(7), 1451-1463 (2013-12-10)
Neurodevelopmental disorders, including autism spectrum disorder (ASD), are defined by core behavioral impairments; however, subsets of individuals display a spectrum of gastrointestinal (GI) abnormalities. We demonstrate GI barrier defects and microbiota alterations in the maternal immune activation (MIA) mouse model
Lauren J Rajakovich et al.
Natural product reports, 36(4), 593-625 (2018-11-20)
Covering: up to the end of 2017 The human body is composed of an equal number of human and microbial cells. While the microbial community inhabiting the human gastrointestinal tract plays an essential role in host health, these organisms have

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