67028
Methylglyoxal solution
technical, ~40% in H2O
Synonym(s):
Acetylformaldehyde, Pyruvaldehyde, Pyruvic aldehyde
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About This Item
Linear Formula:
CH3COCHO
CAS Number:
Molecular Weight:
72.06
Beilstein:
906750
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:
NACRES:
NA.22
Recommended Products
grade
technical
Quality Level
concentration
~40% in H2O
density
1.19 g/mL at 20 °C
functional group
aldehyde
ketone
storage temp.
2-8°C
SMILES string
[H]C(=O)C(C)=O
InChI
1S/C3H4O2/c1-3(5)2-4/h2H,1H3
InChI key
AIJULSRZWUXGPQ-UHFFFAOYSA-N
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General description
Methylglyoxal is a toxic endogenous by-product of glycolysis. It is a reactive dicarbonyl compound that promotes non-enzymatic glycation of proteins to yield irreversible advanced glycated end products, leading to the cross-linking or degradation of proteins.
Application
Methylglyoxal solution is used in cytotoxic studies.
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Eye Dam. 1 - Met. Corr. 1 - Muta. 2 - Skin Sens. 1
Storage Class Code
8A - Combustible corrosive hazardous materials
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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1. Putrescine and spermidine depletion produced by alpha-difluoromethylornithine, an irreversible inhibitor or ornithine decarboxylase (EC 4.1.1.17), resulted in a strikingly enhanced cellular uptake of methylglyoxal bis(guanylhydrazone) in cultured Ehrlich ascites carcinoma cells and human lymphocytic leukemia cells. 2. A prior
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In patients with chronic renal failure, cancer incidence is increased. This may be related to an elevated level of genomic damage, which has been demonstrated by micronuclei formation as well as by comet assay analysis. Advanced glycation end products (AGEs)
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