700048P
Avanti
24(R/S),25-epoxycholesterol-d6
Avanti Research™ - A Croda Brand
Synonym(s):
26,26,26,27,27,27-hexadeutero-24,25-epoxycholesterol
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All Photos(2)
About This Item
Empirical Formula (Hill Notation):
C27H38O2D6
CAS Number:
Molecular Weight:
406.67
UNSPSC Code:
41116107
NACRES:
NA.25
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description
24(R/S),25-epoxycholesterol-d6
Assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 1 mg (700048P-1mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand
shipped in
dry ice
storage temp.
−20°C
General description
24(R/S),25-epoxycholesterol-d6 is a deuterated side-chain substituted oxysterol.
Application
24(R/S),25-epoxycholesterol-d6 has been used as a primary and deuterated surrogate sterol standard in the quantitative analysis of extracted sterol samples from cultured cells and tissues.
Biochem/physiol Actions
24(S),25-epoxycholesterol maintains cholesterol homeostasis. It modulates hepatic cholesterol metabolism in vivo. 24(S),25-epoxycholesterol is synthesized in the mevalonate pathway. It inhibits sterol regulatory element-binding protein (SREBP) activation.
Deuterated sterol plays a vital role in chemical and biochemical research. It is used as a mechanistic tracer to study the role of steroid hormones in the function and modulation of several physiological processes. Deuterated sterol is also used as reference standards for mass spectrometry. 24(R/S),25-epoxycholesterol-d6 is a deuterium labeled sterol.
Packaging
5 mL Amber Glass Screw Cap Vial (700048P-1mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
Storage Class Code
11 - Combustible Solids
Certificates of Analysis (COA)
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Site-specific synthesis and application of Deuterium-Labeled sterols
Muchalski H, et al.
Archive for Organic Chemistry (2017)
Extraction and analysis of sterols in biological matrices by high performance liquid chromatography electrospray ionization mass spectrometry
McDonald J, et al.
Test, 432, 145-170 (2007)
24 (S), 25-epoxycholesterol: a messenger for cholesterol homeostasis
Brown AJ
The International Journal of Biochemistry & Cell Biology, 41(4), 744-747 (2019)
Jeffrey G McDonald et al.
Methods in enzymology, 432, 145-170 (2007-10-24)
We describe the development of a high performance liquid chromatography mass spectrometry (HPLC-MS) method that allows the identification and quantitation of sterols in mammalian cells and tissues. Bulk lipids are extracted from biological samples by a modified Bligh/Dyer procedure in
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