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T1388

Sigma-Aldrich

2-Thiophenecarboxylic acid hydrazide

≥98%

Synonym(s):

2-Thenoylhydrazine, 2-Thienoylhydrazine, 2-Thienyl hydrazide, 2-Thienylcarboxylic acid hydrazide, 2-Thiophenecarbohydrazonic acid, 2-Thiophenecarbonyl hydrazide, 2-Thiophenecarboxylic hydrazide, Thiophene-2-carbohydrazide

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About This Item

Empirical Formula (Hill Notation):
C5H6N2OS
CAS Number:
2361-27-5
Molecular Weight:
142.18
EC Number:
219-107-0
MDL number:
MFCD00005435
UNSPSC Code:
12352100
PubChem Substance ID:
57654655
NACRES:
NA.22

Quality Level

200

Assay

≥98%

form

powder

mp

136-139 °C (lit.)

SMILES string

NNC(=O)c1cccs1

InChI

1S/C5H6N2OS/c6-7-5(8)4-2-1-3-9-4/h1-3H,6H2,(H,7,8)

InChI key

SOGBOGBTIKMGFS-UHFFFAOYSA-N

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Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315,H319,H335

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
BCCL9849
BCCK7744
BCCK0027
BCCH4760
BCCF2223

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Using a novel tissue-clearing method, we aimed to visualize the three-dimensional (3D) distribution of immune cells within Mycobacterium tuberculosis (Mtb)-infected mice lungs. Ethyl cinnamate-based tissue clearing of Mtb-infected mice lungs was performed to obtain transparent lung samples, which were then
J I Moliva et al.
Mucosal immunology, 11(3), 968-978 (2017-09-21)
Current tuberculosis (TB) treatments include chemotherapy and preventative vaccination with Mycobacterium bovis Bacillus Calmette-Guérin (BCG). In humans, however, BCG vaccination fails to fully protect against pulmonary TB. Few studies have considered the impact of the human lung mucosa (alveolar lining
M D Yates et al.
Tubercle, 65(4), 295-299 (1984-12-01)
Thiophen-2-carboxylic acid hydrazide (TCH) is used to distinguish TCH-sensitive bovine, 'Asian human' and 'African' strains from TCH-resistant 'classical' human strains of Mycobacterium tuberculosis. It has been claimed that this test cannot be applied to isoniazid-resistant strains as these also become
Sherry L Kurtz et al.
mSphere, 5(2) (2020-04-17)
Many studies of Mycobacterium tuberculosis infection and immunity have used mouse models. However, outcomes of vaccination and challenge with M. tuberculosis in inbred mouse strains do not reflect the full range of outcomes seen in people. Previous studies indicated that
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Virulence, 11(1), 430-445 (2020-05-15)
Toll-like receptors (TLRs) play critical roles in the innate recognition of Mycobacterium tuberculosis (Mtb) by host immune cells. However, controversy has arisen regarding the role of TLR4 in determining the outcomes of Mtb infection. To address this controversy, the function
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